guanosine-5'-monophosphate tri-n-octylamine salt | 127070-83-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: guanosine-5'-monophosphate tri-n-octylamine salt
• 英文别名: guanosine 5-monophosphate mono(trioctylammonium) salt；[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;N,N-dioctyloctan-1-amine
• CAS: 127070-83-1
• 化学式: C₁₀H₁₄N₅O₈P*C₂₄H₅₁N
• 分子量: 716.899
• InChiKey: GTOGAJLBBUWOKY-YBZOWRFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  49.0
• 可旋转键数：
  25.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  209.28
• 氢给体数：
  6.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  guanosine-5'-monophosphate tri-n-octylamine salt 在 乙二胺四乙酸 、 GDP-mannose pyrophosphorylase 、 sodium perchlorate 、 三丁基焦磷酸铵 、 sodium fluoride 、 magnesium chloride 作用下， 以 乙腈 为溶剂， 反应 48.0h， 生成 guanosine 5'-diphospho-D-mannose
  参考文献：
  名称：

  Convenient syntheses of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate and their use in the preparation of UDP-glucose, UDP-glucuronic acid, and GDP-mannose

  摘要：

  DOI：

  10.1021/jo00293a030
• 作为产物：
  描述：

  三辛胺 、 鸟苷酸 以 甲醇 为溶剂， 生成 guanosine-5'-monophosphate tri-n-octylamine salt
  参考文献：
  名称：

  Pallanca, Jane E.; Turner, Nicolas J., Journal of the Chemical Society. Perkin transactions I, 1993, # 23, p. 3017 - 3022

  摘要：

  DOI：

文献信息

• Chemical Route to the Capped RNAs
  作者：I. I. Koukhareva、A. V. Lebedev

  DOI：10.1081/ncn-200031492

  日期：2004.1.1

  Eukaryotic and viral messenger RNAs contain a CAP structure that plays an important role in the initiation of translation and several other cellular processes that involve mRNAs. In this paper, we report a convenient chemical approach to the preparation of milligram quantities of short, capped RNA oligonucleotides, which overcomes some of the limitations of previous approaches. The method is based on the use of a reactive precursor, m(7)GppQ [P-1-7-methylguanosine-5'-O-yl, p(2)-O-8-(5-chloroquinolyl) pyrophosphate]. The precursor reacts smoothly with 5'-phosphorylated unprotected short RNA in the presence of CuCl2 in organic media. The feasibility of this approach was demonstrated by the synthesis of the capped pentaribonucleotide m(7)GpppGpApCpU. The synthesized capped oligonucleotide was isolated and purified by reverse phase and ion exchange HPLC with a final yield of 37%. The structure of the m(7)GpppGpApCpU was confirmed by P-31 NMR, mass-spectrometry and enzymatic hydrolysis.
• Haikal, H. F.; Chavis, C.; Pompon, A., Bulletin de la Societe Chimique de France, 1989, # 4, p. 521 - 531
  作者：Haikal, H. F.、Chavis, C.、Pompon, A.、Imbach, J.-L.

  DOI：——

  日期：——