(E)-3-hydroxy-N'-((E)-3-(5-nitrofuran-2-yl)allylidene)-2-naphthohydrazide | 1310099-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-hydroxy-N'-((E)-3-(5-nitrofuran-2-yl)allylidene)-2-naphthohydrazide
• 英文别名: 3-hydroxy-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]naphthalene-2-carboxamide
• CAS: 1310099-61-6
• 化学式: C₁₈H₁₃N₃O₅
• 分子量: 351.318
• InChiKey: LPKRLLPOHYNXMW-ABANGTFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-羟基-2-萘酸肼 、 (E)-3-(5-硝基-2-呋喃基)丙烯醛 在 hydrazone 、 ether hexanes 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 以to furnish 172 mg (99%) of the desired product as a yellowish solid的产率得到(E)-3-hydroxy-N'-((E)-3-(5-nitrofuran-2-yl)allylidene)-2-naphthohydrazide
  参考文献：
  名称：

  Hydrazone and diacyl hydrazine compounds and methods of use

  摘要：

  本文介绍了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。同时，还揭示了腙和二酰基肼衍生物作为p97 ATP酶的有效选择性抑制剂。这些药剂提供了研究蛋白质降解和其他涉及p97的过程的有用工具。本文还揭示了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或疾病的方法。

  公开号：

  US08518968B2

文献信息

• [EN] HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS D'HYDRAZONE ET DE DIACYLHYDRAZINE, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：US HEALTH

  公开号：WO2011069039A1

  公开（公告）日：2011-06-09

  Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/ or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.

  本文介绍了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。还披露了腙和二酰基肼衍生物作为p97 ATP酶的有效选择性抑制剂。这些药剂为研究蛋白质降解和其他涉及p97的过程提供了有用的工具。还披露了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或障碍的方法。
• HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE
  申请人：Wiestner Adrian

  公开号：US20120316198A1

  公开（公告）日：2012-12-13

  Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.

  本文披露了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。还披露了腙和二酰基肼衍生物作为p97 ATP酶的有效和选择性抑制剂。这些药剂为研究蛋白降解和其他涉及p97的过程提供了有用的工具。还披露了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或疾病的方法。
• US8518968B2
  申请人：——

  公开号：US8518968B2

  公开（公告）日：2013-08-27
• Hydrazone and diacyl hydrazine compounds and methods of use
  申请人：Wiestner Adrian

  公开号：US08518968B2

  公开（公告）日：2013-08-27

  Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.

  本文介绍了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。同时，还揭示了腙和二酰基肼衍生物作为p97 ATP酶的有效选择性抑制剂。这些药剂提供了研究蛋白质降解和其他涉及p97的过程的有用工具。本文还揭示了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或疾病的方法。