(R)-1-(2-(Trifluoromethyl)pyridin-4-yl)ethan-1-amine | 1256810-98-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (R)-1-(2-(Trifluoromethyl)pyridin-4-yl)ethan-1-amine
• 英文别名: (1R)-1-[2-(trifluoromethyl)pyridin-4-yl]ethanamine
• CAS: 1256810-98-6
• 化学式: C₈H₉F₃N₂
• 分子量: 190.17
• InChiKey: HINKKEGFYGRYTJ-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF<br/>[FR] MODULATEURS D'ENZYMES DE MODIFICATION MÉTHYLIQUE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：CONSTELLATION PHARMACEUTICALS INC

  公开号：WO2016130396A1

  公开（公告）日：2016-08-18

  Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

  提供了式（I）的新化合物及其药学上可接受的盐，这些化合物对治疗与甲基修饰酶相关的各种疾病、疾病或症状有用。还提供了包含式（I）的新化合物、其药学上可接受的盐的药物组合物，以及治疗与甲基修饰酶相关的一种或多种疾病、疾病或症状的使用方法。
• MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
  申请人：Constellation Pharmaceuticals, Inc.

  公开号：US20180037568A1

  公开（公告）日：2018-02-08

  Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.