2-Chloroindazolo[2,3-b]isoquinoline | 185950-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Chloroindazolo[2,3-b]isoquinoline
• CAS: 185950-71-4
• 化学式: C₁₅H₉ClN₂
• 分子量: 252.703
• InChiKey: XAOYVBPAGAPSHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trimethoxonium tetrafluoroborate 、 2-Chloroindazolo[2,3-b]isoquinoline 在 四丁基硫酸氢铵 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以62%的产率得到2-Chloro-5-methylindazolo[2,3-b]isoquinolin-5-ium;hydrogen sulfate
  参考文献：
  名称：

  Synthesis of novel ellipticine analogues and their inhibition of Moloney leukaemia reverse transcriptase

  摘要：

  Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested on Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID50 was found to be in the range of 2.8 to 4.5 x 10(-5) M. \ Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00521-5
• 作为产物：
  描述：

  2,2-dimethyl-N-[4-chloro-2-(3-isoquinolinyl)phenyl]propanamide 在 盐酸 、 sodium azide 、 硫酸 、 sodium acetate 、 sodium nitrite 作用下， 以 various solvent(s) 为溶剂， 反应 5.67h， 生成 2-Chloroindazolo[2,3-b]isoquinoline
  参考文献：
  名称：

  Synthesis of novel ellipticine analogues and their inhibition of Moloney leukaemia reverse transcriptase

  摘要：

  Two new ellipticine analogues were synthetized as potential non nucleoside inhibitors of reverse transcriptase and were tested on Moloney leukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID50 was found to be in the range of 2.8 to 4.5 x 10(-5) M. \ Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00521-5