Methyl 8-bromoquinoxaline-6-carboxylate | 1378260-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Methyl 8-bromoquinoxaline-6-carboxylate
• 英文别名: methyl 8-bromoquinoxaline-6-carboxylate
• CAS: 1378260-25-3
• 化学式: C₁₀H₇BrN₂O₂
• 分子量: 267.08
• InChiKey: FPHVJQGDEZIMJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 8-bromoquinoxaline-6-carboxylate 在 氨 作用下， 以 甲醇 为溶剂， 以76 %的产率得到8-Bromoquinoxaline-6-carboxamide
  参考文献：
  名称：

  COMPOUNDS THAT INHIBIT PKMYT1

  摘要：

  Disclosed herein are compounds according to Formula I. (I). Compounds according to Formula I inhibit PKMYT1 and are useful for the treatment of cancer and other disease. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  公开号：

  WO2024112853A1
• 作为产物：
  描述：

  草酸醛 、 3,4-二氨基-5-溴苯甲酸甲酯 以 乙醇 为溶剂， 以75 %的产率得到Methyl 8-bromoquinoxaline-6-carboxylate
  参考文献：
  名称：

  COMPOUNDS THAT INHIBIT PKMYT1

  摘要：

  Disclosed herein are compounds according to Formula I. (I). Compounds according to Formula I inhibit PKMYT1 and are useful for the treatment of cancer and other disease. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  公开号：

  WO2024112853A1

文献信息

• COMPOUNDS THAT INHIBIT PKMYT1
  申请人：[en]EXELIXIS, INC.

  公开号：WO2024112853A1

  公开（公告）日：2024-05-30

  Disclosed herein are compounds according to Formula I. (I). Compounds according to Formula I inhibit PKMYT1 and are useful for the treatment of cancer and other disease. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.