1-((3,4-dihydroxyphenethyl)amino)-2-methyl-1-oxopropan-2-yl isobutyl carbonotrithioate | 1314094-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-((3,4-dihydroxyphenethyl)amino)-2-methyl-1-oxopropan-2-yl isobutyl carbonotrithioate
• CAS: 1314094-48-8
• 化学式: C₁₇H₂₅NO₃S₃
• 分子量: 387.588
• InChiKey: RYOUCNOMEYGJHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.94
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  69.56
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  succinimidyl 2-(1-isobutyl)sulfanylthiocarbonylsulfanyl-2-methylpropanoate 、 盐酸多巴胺 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以65%的产率得到1-((3,4-dihydroxyphenethyl)amino)-2-methyl-1-oxopropan-2-yl isobutyl carbonotrithioate
  参考文献：
  名称：

  Functionalization of Titanium Surfaces with Polymer Brushes Prepared from a Biomimetic RAFT Agent

  摘要：

  Well-defined dopamine end-functionalized polymers were synthesized by employing the reversible addition fragmentation chain transfer (RAFT) polymerization technique. tert-Butyl acrylate, N-isopropylacrylamide, and styrene monomers were polymerized in the presence of azobis (isobutyronitrile) and a new catechol-based biomimetic RAFT agent incorporating a trithiocarbonate unit. All RAFT polymerizations exhibited pseudofirst-order kinetics, a linear increase of the number-average molar mass (M-n SEC) with conversion and narrow molar mass distributions (polydispersity <1.2). The resulting homopolymers exhibited the electroactive catechol and the omega-trithiocarbonyl end groups. Subsequent immobilization of dopamine end-functionalized polymers on titanium surfaces was monitored by using a surface plasmon resonance (SPR) sensor, and the resulting films were characterized by contact angle, infrared ATR spectroscopy, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS).

  DOI：

  10.1021/ma200853w