8-(2-Cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine | 1231298-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-(2-Cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine
• CAS: 1231298-94-4
• 化学式: C₂₅H₃₂N₆O
• 分子量: 432.569
• InChiKey: XKHSPPXRUZWOPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  59.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-(2-Cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine 在 盐酸 作用下， 以 乙醚 、 水 、 丙酮 、 乙腈 为溶剂， 反应 1.0h， 生成 8-(2-cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-tetrahydropyran-4-yl-purine hydrochloride
  参考文献：
  名称：

  Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain

  摘要：

  A focused screening strategy identified thienopyrimidine 12 as a cannabinoid receptor type 2 agonist (hCB2) with moderate selectivity over the hCB1 receptor. This initial hit suffered from poor in vitro metabolic stability and high in vivo clearance. Structure-activity relationships describe the optimization and modification to a new more polar series of purine CB2 agonists. Examples from this novel scaffold were found to be highly potent and fully efficacious agonists of the human CB2 receptor with excellent selectivity against CBI, often having no CBI agonist activity at the highest concentration measured (>100 mu M). Compound 26 is a centrally penetrant molecule which possesses good biopharmaceutical properties, is highly water-soluble, and demonstrates robust oral activity in rodent models of joint pain. In addition, the peripherally restricted molecule 22 also demonstrated significant efficacy in the same analgesic model of rodent inflammatory pain.

  DOI：

  10.1021/jm400305d
• 作为产物：
  描述：

  2-甲基-4,6-二氯-5-氨基嘧啶 在 氨 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 水 、 异丙醇 为溶剂， 反应 38.0h， 生成 8-(2-Cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine
  参考文献：
  名称：

  Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain

  摘要：

  A focused screening strategy identified thienopyrimidine 12 as a cannabinoid receptor type 2 agonist (hCB2) with moderate selectivity over the hCB1 receptor. This initial hit suffered from poor in vitro metabolic stability and high in vivo clearance. Structure-activity relationships describe the optimization and modification to a new more polar series of purine CB2 agonists. Examples from this novel scaffold were found to be highly potent and fully efficacious agonists of the human CB2 receptor with excellent selectivity against CBI, often having no CBI agonist activity at the highest concentration measured (>100 mu M). Compound 26 is a centrally penetrant molecule which possesses good biopharmaceutical properties, is highly water-soluble, and demonstrates robust oral activity in rodent models of joint pain. In addition, the peripherally restricted molecule 22 also demonstrated significant efficacy in the same analgesic model of rodent inflammatory pain.

  DOI：

  10.1021/jm400305d

文献信息

• Purine Compounds
  申请人：ASTLES Peter Charles

  公开号：US20100160288A1

  公开（公告）日：2010-06-24

  A compound of the formula: and pharmaceutical compositions for the treatment of pain.

  该化合物的分子式为，并且用于治疗疼痛的药物组合。
• PURINE COMPOUNDS
  申请人：Eli Lilly and Company

  公开号：EP2379555B1

  公开（公告）日：2015-02-25
• US8252798B2
  申请人：——

  公开号：US8252798B2

  公开（公告）日：2012-08-28
• [EN] PURINE COMPOUNDS<br/>[FR] COMPOSÉS PURINES
  申请人：LILLY CO ELI

  公开号：WO2010080306A1

  公开（公告）日：2010-07-15

  A compound of the formula and pharmaceutical compositions for the treatment of pain.
• Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain
  作者：Sean P. Hollinshead、Michael W. Tidwell、John Palmer、Rossella Guidetti、Adam Sanderson、Michael P. Johnson、Mark G. Chambers、Jennifer Oskins、Robert Stratford、Peter C. Astles

  DOI：10.1021/jm400305d

  日期：2013.7.25

  A focused screening strategy identified thienopyrimidine 12 as a cannabinoid receptor type 2 agonist (hCB2) with moderate selectivity over the hCB1 receptor. This initial hit suffered from poor in vitro metabolic stability and high in vivo clearance. Structure-activity relationships describe the optimization and modification to a new more polar series of purine CB2 agonists. Examples from this novel scaffold were found to be highly potent and fully efficacious agonists of the human CB2 receptor with excellent selectivity against CBI, often having no CBI agonist activity at the highest concentration measured (>100 mu M). Compound 26 is a centrally penetrant molecule which possesses good biopharmaceutical properties, is highly water-soluble, and demonstrates robust oral activity in rodent models of joint pain. In addition, the peripherally restricted molecule 22 also demonstrated significant efficacy in the same analgesic model of rodent inflammatory pain.