2,6-Dioxabicyclo(3.2.1)octane | 280-00-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧环庚烷
• 英文名称: 2,6-Dioxabicyclo(3.2.1)octane
• 英文别名: 2,6-dioxabicyclo[3.2.1]octane
• CAS: 280-00-2
• 化学式: C₆H₁₀O₂
• 分子量: 114.14
• InChiKey: UCTGPBWORFETEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel nucleosides having bicyclic sugar moiety
  申请人：——

  公开号：US20030028013A1

  公开（公告）日：2003-02-06

  Conformationally restricted 2′, 4′-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients, and especially for use in treatment of HCV.

  本文描述了构象受限的2′，4′-桥接核苷类似物。这些化合物可以通过在核苷的C2′和C4′处通过连接物或连接分子进行环化来制备。这些新型核苷具有所需的锁定糖环形，并且可能作为药用成分，特别是用于HCV的治疗。
• BRIDGED BICYCLIC NUCLEOSIDES
  申请人：MIRAGEN THERAPEUTICS, INC.

  公开号：US20160010090A1

  公开（公告）日：2016-01-14

  The present invention relates to 2′-C-Bridged Bicyclic Nucleosides and Nucleotides, and oligonucleotides comprising at least one 2′-C-Bridged Bicyclic Nucleotides. The present invention further provides pharmaceutical compositions comprising the nucleosides, nucleotides, and oligonucleotides, as well as their respective methods of use and synthesis.

  本发明涉及2'-C-桥接双环核苷和核苷酸，以及包含至少一个2'-C-桥接双环核苷的寡核苷酸。本发明还提供包含这些核苷、核苷酸和寡核苷酸的药物组合物，以及它们各自的使用和合成方法。
• Bridged bicyclic nucleosides
  申请人：MIRAGEN THERAPEUTICS, INC.

  公开号：US10011833B2

  公开（公告）日：2018-07-03

  The present invention relates to 2′-C-Bridged Bicyclic Nucleosides and Nucleotides, and oligonucleotides comprising at least one 2′-C-Bridged Bicyclic Nucleotides. The present invention further provides pharmaceutical compositions comprising the nucleosides, nucleotides, and oligonucleotides, as well as their respective methods of use and synthesis.

  本发明涉及2′-C-桥双环核苷和核苷酸，以及包含至少一种2′-C-桥双环核苷酸的寡核苷酸。本发明进一步提供了包含核苷酸、核苷酸和寡核苷酸的药物组合物，以及它们各自的使用和合成方法。
• 2H-INDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：Biogen MA Inc.

  公开号：EP3990432A1

  公开（公告）日：2022-05-04
• IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
  申请人：Biogen MA Inc.

  公开号：EP3990454A1

  公开（公告）日：2022-05-04