adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline | 391219-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline
• CAS: 391219-37-7
• 化学式: C₁₉H₂₄ClNO
• 分子量: 317.859
• InChiKey: CWJUYUZOXNPNRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  cobalt(II) chloride hexahydrate 、 adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以58%的产率得到
  参考文献：
  名称：

  Synthesis, characterization, and crystal structure of three cobalt(II) complexes with Schiff bases derived from rimantadine

  摘要：

  By condensation of rimantadine and substituted salicylaldehyde, three new Schiff bases, HL1, HL2 and HL3, were synthesized. Then, a mixture of one of the new ligands and cobalt(II) chloride hexahydrate in ethanol led to 1, 2, and 3, respectively. These complexes were characterized by melting point, elemental analysis, infrared spectra, molar conductance, thermal analysis, and single-crystal X-ray diffraction analysis. X-ray diffraction analysis reveals that 1 crystallizes in the orthorhombic system, Pbcn space group; each asymmetric unit consists of one cobalt(II) ion, two deprotonated ligands, and one lattice water. The central cobalt is four coordinate via two nitrogens and two oxygens from the corresponding Schiff base ligand, forming a distorted tetrahedral geometry. Complexes 2 and 3 crystallize in the monoclinic system, P2(1)/c space group; each asymmetric unit consists of one cobalt(II), two corresponding deprotonated ligands, one lattice water, and one methanol. The central cobalt is also four-coordinate via two nitrogens and two oxygens from the corresponding Schiff base ligand, forming a distorted tetrahedral geometry.

  DOI：

  10.1080/00958972.2014.885509
• 作为产物：
  描述：

  盐酸金刚乙胺 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 adamantyl-N-(ethyl)-(5-chlorosalicylidene)aniline
  参考文献：
  名称：

  Synthesis, characterization, and crystal structure of three cobalt(II) complexes with Schiff bases derived from rimantadine

  摘要：

  By condensation of rimantadine and substituted salicylaldehyde, three new Schiff bases, HL1, HL2 and HL3, were synthesized. Then, a mixture of one of the new ligands and cobalt(II) chloride hexahydrate in ethanol led to 1, 2, and 3, respectively. These complexes were characterized by melting point, elemental analysis, infrared spectra, molar conductance, thermal analysis, and single-crystal X-ray diffraction analysis. X-ray diffraction analysis reveals that 1 crystallizes in the orthorhombic system, Pbcn space group; each asymmetric unit consists of one cobalt(II) ion, two deprotonated ligands, and one lattice water. The central cobalt is four coordinate via two nitrogens and two oxygens from the corresponding Schiff base ligand, forming a distorted tetrahedral geometry. Complexes 2 and 3 crystallize in the monoclinic system, P2(1)/c space group; each asymmetric unit consists of one cobalt(II), two corresponding deprotonated ligands, one lattice water, and one methanol. The central cobalt is also four-coordinate via two nitrogens and two oxygens from the corresponding Schiff base ligand, forming a distorted tetrahedral geometry.

  DOI：

  10.1080/00958972.2014.885509

文献信息

• Synthesis, characterization and interaction with bovine serum albumin of cyclometallated Pd(II) complexes containing arylimine and salicylaldimine co-ligands
  作者：Xu-Dong Jin、Yajing Yang、Yuchun Jiang、Xiang Han、Xiaowen Wan、Daliang Liu、Xi-Ming Song、Xiaohong Chang

  DOI：10.1016/j.jorganchem.2015.04.050

  日期：2015.8

  Cyclometallated Pd(II) complexes containing arylimine and salicylaldimine co-ligands were synthesized by the reactions of cyclopalladated chloro dimers [Pd(4-R)C6H3CH=N-C6H3-2,6-i-Pr-2}(mu-Cl)](2) (R - H; OMe) with salen-based ligands derived from rimantadine. The complexes were characterized by FTIR, NMR spectroscopy, elemental analysis and X-ray crystallography. Interaction of cyclometallated Pd(II) complexes with BSA was studied by fluorescence and synchronous fluorescence spectroscopy. The fluorescence intensities of protein are decreased gradually with increasing concentration of complexes. In the synchronous fluorescence spectra of BSA at Delta lambda = 15 nm and Delta lambda = 60 nm, the fluorescence of intensities of protein also are decreased with increasing concentration of complexes. (C) 2015 Elsevier B.V. All rights reserved.