4.5-二氯荧光黄4.5-二氯-3.6-荧烷二醇 | 2320-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 4.5-二氯荧光黄4.5-二氯-3.6-荧烷二醇
• 中文别名: 4’,5’-二氯荧光素；4,5-二氯萤光素；4,5-二氯荧光素；4ˊ,5ˊ-二氯荧光素；4ˊ,5ˊ-二氯萤光黄
• 英文名称: 4',5'-Dichlorofluorescein
• 英文别名: DCFS；4',5'-dichloro-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one；4',5'-Dichlor-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；4',5'-dichloro-3',6'-dihydroxyspiro(isobenzofuran-1[3H]-9'-[9H]-xanthene)-3-one；4',5'-dichloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 2320-96-9
• 化学式: C₂₀H₁₀Cl₂O₅
• 分子量: 401.202
• InChiKey: WLHLYHWMNUCWEV-UHFFFAOYSA-N

物化性质

• 沸点：
  633.9±55.0 °C(Predicted)
• 密度：
  1.75±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2932999099

制备方法与用途

用途：银量法测定卤素时常使用其作为吸附指示剂。

文献信息

• Synthetic molecules for labeling histidine-rich proteins
  申请人：——

  公开号：US20040143122A1

  公开（公告）日：2004-07-22

  The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn 2+ 0 ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni-based labeling systems. Invention Zn-chelating compounds also do not require oxidizable thiols and therefore can be used in non-reducing environments such as the surface of living cells. In addition, the target sequence is genetically encodable and requires incorporation of only a few amino acids, unlike fusions to fluorescent proteins such as GFP.

  这项发明提供了分子工程设计的Zn螯合化合物，可以结合到感兴趣蛋白质中的特定靶标序列。Zn2+0离子比镍毒性和广泛性要小得多，因此是镍基标记系统的一个有吸引力的替代选择。该发明的Zn螯合化合物也不需要可氧化的硫醇，因此可以在非还原环境中使用，比如生物细胞表面。此外，靶标序列是遗传可编码的，只需要引入少量氨基酸，不像与荧光蛋白（如GFP）融合那样需要。
• Drug delivery system for hydrophobic drugs
  申请人：QLT, Inc.

  公开号：EP1900357A2

  公开（公告）日：2008-03-19

  Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.

  本文介绍了由含有疏水性药物的微团聚体组成的组合物及其生产方法。这种微团聚体可包括胶束结构或其与脂质体的组合，并构成疏水性药物的有效递送载体。微团聚体的生产方法包括使用优选的脂质化合物和有利于生产小团聚体的加工条件，以提高过滤灭菌效果。
• Improved Topical Medicaments and Methods for Photodynamic Treatment of Disease
  申请人：Provectus Pharmatech, Inc.

  公开号：EP2020242A2

  公开（公告）日：2009-02-04

  New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

  本文描述了用于治疗人类或动物组织的新型光动力局部应用药物及其某些医疗用途，其中此类药物的主要活性成分是卤代呫吨。卤代呫吨构成了一个强效光敏剂家族，当治疗部位受到可见光波长的照射时，卤代呫吨会被光激活。在优选的实施方案中，此类药物用于治疗影响皮肤和相关器官、口腔和消化道及相关器官、泌尿道和生殖道及相关器官、呼吸道及相关器官、各种其他内部或外部组织表面，如手术中暴露的组织表面的各种病症，以及治疗与微生物或寄生虫感染有关的各种病症。在另一个优选的实施方案中，这类药物以各种配方生产，包括液体、半固体或气溶胶给药载体。
• Biophotonic materials and uses thereof
  申请人：KLOX TECHNOLOGIES INC.

  公开号：US10130706B2

  公开（公告）日：2018-11-20

  The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least chromophore which can absorb and emit light from within the topical biphotonic material, wherein the topical biophotonic material is elastic. The topical biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

  本公开提供了用于光疗的局部生物光子材料和方法。特别是，本公开的局部生物光子材料包括粘性基质，以及至少能从局部双光子材料内部吸收和发射光的发色团，其中局部生物光子材料具有弹性。本公开的外用生物光子材料和方法可用于促进伤口愈合和嫩肤，以及治疗痤疮和其他各种皮肤疾病。
• Tissue filler compositions and methods of use
  申请人：KLOX Technologies Inc.

  公开号：US10207029B2

  公开（公告）日：2019-02-19

  The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.

  本公开涉及刺激胶原蛋白合成、软组织美容增强和/或抑制或治疗瘢痕的方法，包括向软组织内待治疗区域施用组合物，其中组合物包括组织填充介质和荧光团；以及用具有可被荧光团吸收的波长的光照射该区域。