4H-1,3-噁嗪,2-(丁基硫代)-5,6-二氢-4,4,6-三甲基- | 841-18-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 4H-1,3-噁嗪,2-(丁基硫代)-5,6-二氢-4,4,6-三甲基-
• 英文名称: (E)-1-(4-acetamidophenyl)-2-phenylethene
• 英文别名: (E)-N-(4-styrylphenyl)acetamide；trans-4-acetamidostilbene；4-acetylaminostilbene；p-acetamidostilbene；N-trans-stilben-4-yl-acetamide；N-trans-Stilben-4-yl-acetamid；N-[4-[(E)-2-phenylethenyl]phenyl]acetamide
• CAS: 841-18-9
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: XWVCGVPSPHTRHE-BQYQJAHWSA-N

物化性质

• 沸点：
  379.83°C (rough estimate)
• 密度：
  1.0479 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 安全说明：
  Sx."

反应信息

• 作为产物：
  描述：

  (Z)-N-(4-styrylphenyl)acetamide 在 碘 、 苯 作用下， 生成 4H-1,3-噁嗪,2-(丁基硫代)-5,6-二氢-4,4,6-三甲基-
  参考文献：
  名称：

  Stoermer; Oehlert, Chemische Berichte, 1922, vol. 55, p. 1241

  摘要：

  DOI：

文献信息

• Acetamidoarenediazonium Salts: Opportunities for Multiple Arene Functionali­zation
  作者：Bernd Schmidt、Nelli Elizarov、Nastja Riemer、Frank Hölter

  DOI：10.1002/ejoc.201500795

  日期：2015.9

  Unlike their ortho counterparts, meta- and para-acetamidoanilines can be converted into the corresponding acetamidoarenediazonium salts. These offer various opportunities for multiple Pd-catalyzed arene functionalization reactions, such as Matsuda-Heck-, Suzuki-Miyaura- or Fujiwara-Moritani couplings.

  与它们的邻位对应物不同，间和对乙酰氨基苯胺可以转化为相应的乙酰氨基芳烃重氮盐。这些为多种 Pd 催化的芳烃官能化反应提供了各种机会，例如 Matsuda-Heck-、Suzuki-Miyaura- 或 Fujiwara-Moritani 偶联。
• A Solid‐Phase Assisted Flow Approach to <i>In Situ</i> Wittig‐Type Olefination Coupling
  作者：Joseph Tadros、Christian Dankers、Janice R. Aldrich‐Wright、Anastasios Polyzos、Christopher P. Gordon

  DOI：10.1002/ejoc.202100761

  日期：2021.8.6

  The development and subsequent application of an in situ and solid-phase triphenylphosphine (PS-PPh3) assisted continuous flow protocol to facilitate the coupling of reciprocal primary and secondary halides with aldehyde and ketone-based substrates is described.

  的发展和一个随后的应用在 原位和固相的三苯基膦（PS-PPH 3）辅助的连续流协议，以促进描述与醛和酮系基板倒数初级和次级卤化物的耦合。
• A Mild Chemoselective Ru-Catalyzed Reduction of Alkynes, Ketones, and Nitro Compounds
  作者：Tobias Schabel、Christian Belger、Bernd Plietker

  DOI：10.1021/ol401185t

  日期：2013.6.7

  The chemoselective reduction of alkyne, ketones, or nitro groups using (Ph3P)3RuCl2 as an inexpensive catalyst and Zn/water as a stoichiometric reductant is reported. Depending on the nature of the additive and the temperature, good chemoselectivities were observed allowing, e.g., for the selective reduction of a nitro group in the presence of a ketone or an alkyne.

  报道了使用（Ph 3 P）3 RuCl 2作为廉价催化剂和Zn /水作为化学计量还原剂的炔，酮或硝基的化学选择性还原。取决于添加剂的性质和温度，观察到良好的化学选择性，例如允许在酮或炔烃的存在下选择性还原硝基。
• Aryl–aryl interactions as directing motifs in the stereodivergent iron-catalyzed hydrosilylation of internal alkynes
  作者：Christian Belger、Bernd Plietker

  DOI：10.1039/c2cc31395b

  日期：——

  The defined Fe hydride complex FeH(CO)(NO)(Ph3P)2 is highly active as a catalyst for selective hydrosilylation of internal alkynes to vinylsilanes. Depending on the silane employed either E- or Z-selective hydrosilylation products were formed in excellent yields and good to excellent stereoselectivities.

  定义的氢化铁络合物 FeH(CO)(NO)(Ph3P)2 作为催化剂在选择性氢硅化内部炔烃转化为乙烯硅烷方面具有很高的活性。根据所用的硅烷，产生了 E- 或 Z- 选择性的氢硅化产物，产率优异，立体选择性良好到优异。
• <i>E</i>-Selective Semi-hydrogenation of Alkynes with Dinuclear Iridium Complexes under Atmospheric Pressure of Hydrogen
  作者：Kosuke Higashida、Kazushi Mashima

  DOI：10.1246/cl.160410

  日期：2016.8.5

  Semi-hydrogenation of alkynes was catalyzed by halide-bridged dinuclear iridium complexes, yielding (E)-alkenes with high selectivity. Mechanistic studies conducted with monohydride dinuclear species, dihydride mononuclear species, and trihydride dinuclear species led us to propose a mechanism involving dual cycles.

  炔烃的半氢化由卤化物桥连的双核铱配合物催化，产生具有高选择性的（E）-烯烃。对一氢化物双核物质、二氢化物单核物质和三氢化物双核物质进行的机理研究使我们提出了一种涉及双循环的机制。