Oxyterracin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: Oxyterracin
• 英文别名: 4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide；oxytetracycline；Oxytetracyclin；5-Hydroxy-tetracyclin
• 化学式: C₂₂H₂₄N₂O₉
• mdl: MFCD00066878
• 分子量: 460.441
• InChiKey: IWVCMVBTMGNXQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.24
• 重原子数：
  33.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  201.85
• 氢给体数：
  7.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  Oxyterracin 在 二苯甲酮 、 二苯甲醇 作用下， 反应 3.0h， 生成 Lumioxytetracycline
  参考文献：
  名称：

  Organic photochemistry. 92. Formation and characterization of lumitetracycline-type photoproducts from members of the tetracycline family

  摘要：

  DOI：

  10.1021/jo00016a030

文献信息

• Compositions and methods for treating hemorrhagic virus infections and other disorders
  申请人：——

  公开号：US20020077276A1

  公开（公告）日：2002-06-20

  Cytokine-receptor and cytokine antagonist-enriched blood-dervided compositions and methods of preparing and using the compositions are provided. Also provided are compositions and methods for the treatment or prevention of disorders, especially acute inflammatory disorders involving pathological responses of the immune system, such as viral hemorrhagic diseases, sepsis, rheumatoid arthritis and other autoimmune disorders, acute cardiovascular events, flare-ups and acute phases of multiple sclerosis, wasting disorders and other disorders involving deleterious expression of cytokines and other factors, including tumor necrosis factor (TNF) and interleukin-1 (IL-1) are provided.

  提供了富含细胞因子受体和细胞因子拮抗剂的血液衍生物组合物的制备和使用方法。还提供了用于治疗或预防疾病的组合物和方法，特别是涉及免疫系统病理反应的急性炎症性疾病，如病毒性出血热疾病、败血症、类风湿关节炎和其他自身免疫性疾病、急性心血管事件、多发性硬化的急性阶段、消耗性疾病和其他涉及细胞因子和其他因子有害表达的疾病，包括肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）。
• 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20160031802A1

  公开（公告）日：2016-02-04

  The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

  本发明涉及新型的3、10和/或12a-取代四环素化合物。这些四环素化合物可用于治疗多种四环素化合物敏感状态，如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的应用，如阻止四环素外流和基因表达调节。
• 7-phenyl-substituted tetracycline compounds
  申请人：Nelson L. Mark

  公开号：US20070155708A1

  公开（公告）日：2007-07-05

  7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.

  本文介绍了7-苯基取代四环素化合物、治疗对四环素敏感状态的方法以及含有7-苯基取代四环素化合物的制药组合物。
• 7-Phenyl-Substituted Tetracycline Compounds
  申请人：Nelson Mark L.

  公开号：US20080306032A1

  公开（公告）日：2008-12-11

  7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.

  本文描述了7-苯基取代四环素化合物，其基本上不含位置异构体，以及治疗四环素反应状态的方法和含有7-苯基取代四环素化合物的制药组合物。还描述了基本上不含位置异构体的7-取代四环素化合物，以及治疗四环素反应状态的方法和含有7-取代四环素化合物的制药组合物。
• Photocatalytic degradation and pathway of oxytetracycline in aqueous solution by Fe₂O₃–TiO₂ nanopowder
  作者：Rong Li、Yuefa Jia、Jun Wu、Qiang Zhen

  DOI：10.1039/c5ra04540a

  日期：——

  After photocatalytic degradation under UV/visible light by Fe₂O₃/TiO₂ composites, the naphthol ring of oxytetracycline (C₂₂H₂₄N₂O₉) destructed to a partial ring-ruptured structure, such as C₉H₆O₄.

  在紫外/可见光下，Fe2O3/TiO2 复合材料进行光催化降解后，土霉素（C22H24N2O9）的萘酚环破坏成部分破环结构，如 C9H6O4。