[(2-formyl-3,4-dimethoxyphenyl)-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methyl] acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: [(2-formyl-3,4-dimethoxyphenyl)-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methyl] acetate
• 化学式: C₂₄H₂₇NO₈
• 分子量: 457.5
• InChiKey: JUUOWVIBIPDOSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  92.8
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Compositions and methods for making noscapine and synthesis intermediates thereof
  申请人：Willow BioSciences Inc.

  公开号：US10793885B2

  公开（公告）日：2020-10-06

  Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.

  生产治疗用化学合成物诺卡平和诺卡平合成中间体的方法，包括将选自第一卡那定衍生物、第一罂粟碱衍生物和麻醉品半缩醛的诺卡平途径前体与选自CYP82Y1、CYP82X1、AT1、CYP82X2、OMT、CXE1和NOS组的至少一种酶接触。
• COMPOSITIONS AND METHODS FOR MAKING NOSCAPINE AND SYNTHESIS INTERMEDIATES THEREOF
  申请人：EPIMERON INC.

  公开号：US20160201101A1

  公开（公告）日：2016-07-14

  Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.