6,7-dihydroxyisoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 6,7-dihydroxyisoquinoline
• 英文别名: 6,7-Dihydroxyisoquinoline；isoquinoline-6,7-diol
• 化学式: C₉H₇NO₂
• mdl: MFCD18448578
• 分子量: 161.16
• InChiKey: LOIDKAGDLUKYNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-dihydroxyisoquinoline 、 Benzhydryl 7-[(Z)-2-methoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-iodomethyl-3-cephem-4-carboxylate 1-oxide 生成 benzhydryl (6R)-3-[(6,7-dihydroxyisoquinolin-2-ium-2-yl)methyl]-7-[[(2Z)-2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-5,8-dioxo-5λ4-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;iodide
  参考文献：
  名称：

  NAKAGAWA, SUSUMU;OTAKE, NORIKAZU;USHIJIMA, RYOSUKE

  摘要：

  DOI：
• 作为产物：
  描述：

  6,7-二甲氧基异喹啉 生成 6,7-dihydroxyisoquinoline
  参考文献：
  名称：

  XARADA, TOSIAKI;JOSIDZATO, AKINOBU;IMAI, YUSI;KANO, YASUNOBU;ITIKAVA, YAT+

  摘要：

  DOI：

文献信息

• Cephem Compounds with Latent Reactive Groups
  申请人：Gladius Pharmaceuticals, Inc.

  公开号：US20190100534A1

  公开（公告）日：2019-04-04

  Cephem and penem compounds having a styrylmethylene moiety at the 3-position in the cephem or penem ring to which a positively charged leaving group is bonded and wherein the leaving group contains a vicinal diol or is bonded to a unsubstituted or substituted catechol. The leaving group can be a positively charge nitrogen leaving group. Cephems include cephalosporins, cephamycins, carbacephems, and oxacephems. Penems include penems, carbapenems and oxapenems. Preferred cephems are cephalosporins. Preferred penems are carbapenems. Compounds exhibit antibiotic activity against Gram-negative bacteria and/or Gram-positive bacteria. Compounds exhibit antibiotic activity against bacteria which exhibit multi-drug resistance. Compounds of the invention exhibit antibiotic activity against bacterial strains which produce extended spectrum beta-lactamases (ESBL), which produce AmpC beta-lactamases or which produce a carbapenemase. Pharmaceutical compositions comprising one or more cephems or penems or methods of treatment of bacterial infections with such compounds and compositions.

  具有在头孢菌素或青霉烷素环中3位处具有苯乙烯亚甲基基团的头孢菌素和青霉烷素化合物，其中正电离子离去基团与离去基团中含有邻二醇或连接到未取代或取代过的邻苯二酚。离去基团可以是正电离子离去基团。头孢菌素包括头孢菌素、头孢菌烷、卡巴头孢菌素和氧头孢菌素。青霉烷素包括青霉烷素、碳青霉烷素和氧青霉烷素。首选头孢菌素是头孢菌素。首选青霉烷素是碳青霉烷素。化合物对革兰氏阴性细菌和/或革兰氏阳性细菌表现出抗生素活性。化合物对表现出多重耐药性的细菌表现出抗生素活性。本发明的化合物表现出抗生素活性，对产生扩展谱β-内酰胺酶（ESBL）、产生AmpCβ-内酰胺酶或产生碳青霉烷酶的细菌菌株表现出抗生素活性。包括一种或多种头孢菌素或青霉烷素的制药组合物或使用这些化合物和组合物治疗细菌感染的方法。
• NEW COMPOUNDS HAVING TRIPLE ACTIVITIES OF THROMBOLYSIS, ANTITHROMBOTIC AND RADICAL SCAVENGING, AND SYNTHESIS, NANO-STRUCTURE AND USE THEREOF
  申请人：Shanghai Lumosa Therapeutics Co., Ltd.

  公开号：US20160083423A1

  公开（公告）日：2016-03-24

  The present invention relates to a compound simultaneously having triple activities of thrombolysis, antithrombosis and free radical scavenging, as well as the preparation method, composition, and applications thereof. The compound is represented by the formula I shown below: wherein the definitions of T, Q, R 1 and R 2 are described herein. The compound of the present invention simultaneously has triple functions of thrombolysis, free radical scavenging and thrombus-targeting/antithrombosis. The present invention also relates to a pharmaceutical composition comprising the compound, and a preparation method and a nanostructure of the compound.

  本发明涉及一种具有溶栓、抗血栓和自由基清除三重活性的化合物，以及其制备方法、组成和应用。该化合物由下式I所示：其中T、Q、R1和R2的定义在此描述。本发明的化合物同时具有溶栓、自由基清除和靶向/抗血栓三重功能。本发明还涉及一种包含该化合物的制药组合物，以及化合物的制备方法和纳米结构。
• Cephalosporin derivatives, processes for their preparation and
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US04782155A1

  公开（公告）日：1988-11-01

  The compound having the formula: ##STR1## wherein R.sup.6 is a hydrogen atom or an alkanoyl group, or a salt thereof and a process thereof.

  该化合物的化学式为：##STR1##其中R.sup.6为氢原子或脂肪酰基，或其盐，以及其制备方法。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• Cephalosporin derivatives, processes for their preparation and antibacterial agents
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP0238060A2

  公开（公告）日：1987-09-23

  The compound having the formula: wherein R is a straight chain, branched chain or cyclic lower alkyl, a lower alkenyl or a lower alkynyl group which may be substituted by a carboxyl group, and R¹ is hydrogen atom or an acetyl group; or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, processes for the preparation thereof, and an antibacterial agent containing it. Also disclosed are a compound having the formula: wherein R⁶ is a hydrogen atom or an alkanoyl group, or a salt thereof and a process thereof.

  式中 R 为可被羧基取代的直链、支链或环状低级烷基、低级烯基或低级炔基，R¹ 为氢原子或乙酰基的化合物；或其药学上可接受的盐、生理上可水解的酯或溶液、其制备工艺以及含有该化合物的抗菌剂。 还公开了一种化合物，其式为： 其中 R⁶ 是氢原子或烷酰基，或其盐及其工艺。