4-methyl-5-propan-2-yl-3,6-dihydro-2H-thiopyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: 4-methyl-5-propan-2-yl-3,6-dihydro-2H-thiopyran
• 化学式: C₉H₁₆S
• 分子量: 156.29
• InChiKey: CEXREFQHTVQXGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10806724B2

  公开（公告）日：2020-10-20

  The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected from: and ring B, n, R1, R2, R2A, R3, and R3A are as defined herein. The compounds of the invention are useful as mGluR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.

  本发明提供了某些取代的式 (I) 的铬烷、异铬烷和二氢异苯并呋喃化合物： 或其药学上可接受的盐，其中环 A 是选自以下的分子 和环 B、n、R1、R2、R2A、R3 和 R3A 如本文所定义。本发明的化合物可用作 mGluR2 抑制剂或 mGluR2 负性异位调节剂 (NAM)，并可用于通过向患者施用治疗有效量的本发明化合物或其药学上可接受的盐，来治疗患者涉及 mGluR2-NAM 受体的疾病或紊乱，如阿尔茨海默病、认知障碍、轻度认知障碍、精神分裂症和其他情绪紊乱、疼痛紊乱和睡眠紊乱。本发明还涉及包含本发明化合物或其药学上可接受的盐的药物组合物（可选择与一种或多种其它活性成分组合）和药学上可接受的载体，以及本发明化合物和药物组合物在治疗此类疾病中的用途。
• 4, 5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS
  申请人：Anilkumar Gopinadhan N.

  公开号：US20100196319A1

  公开（公告）日：2010-08-05

  The present invention relates to 4,5-ring annulated indole derivatives of formula (I), compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient, wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R 1 , R 2 , R 3 , R 6 , R 7 and R 10 are as described herein.
• CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20190247374A1

  公开（公告）日：2019-08-15

  The present invention provides certain substituted chromane, isochromane, and dihydroisobenzofuran compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A is a moiety selected from: and ring B, n, R 1 , R 2 , R 2A , R 3 , and R 3A are as defined herein. The compounds of the invention are useful as mGluR2 inhibitors, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a patient for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, mild congnitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.
• [EN] 4, 5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS<br/>[FR] DÉRIVÉS CONDENSÉS À 4,5 NOYAUX DESTINÉS AU TRAITEMENT OU À LA PRÉVENTION DU VHC ET DES INFECTIONS VIRALES ASSOCIÉES
  申请人：SCHERING CORP

  公开号：WO2008082488A1

  公开（公告）日：2008-07-10

  [EN] The present invention relates to 4, 5 - ring annulated indole derivatives of formula ( I ), compositions comprising at leas t one 4, 5 - ring annulated indole derivatives, and methods of using the 4, 5 - ring annulated ^ndole derivatives for treating or preventing a viral inf ection or a virus - related disorder in a patient, (I) wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6- membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R¹, R², R³, R⁶. R⁷ and R¹⁰ are as described herein.
  [FR] L'invention concerne des dérivés indole condensés à 4,5 noyaux de la formule (I), des compositions renfermant au moins un dérivé indole condensé à 4,5 noyaux, et des procédés d'utilisation des dérivés indole condensés à 4,5 noyaux dans le traitement ou la prévention d'une infection virale ou d'un trouble lié à un virus chez un patient, (I) le cycle Z de la formule (I) étant cyclohexyle, cyclohexényle, hétérocycloalkyle à 6 chaînons, hétérocycloalcényle à 6 chaînons, aryle à 6 chaînons ou hétéroaryle à 6 chaînons, où R¹, R², R³, R⁶, R⁷ et R¹⁰ sont tels que définis dans la description.