11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• 英文别名: 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₉H₃₉NO₃
• 分子量: 449.6
• InChiKey: IEXUMDBQLIVNHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Methods of reducing incidence of stillborn pigs by using progesterone receptor antagonists
  申请人：Pfizer Inc

  公开号：US20040074447A1

  公开（公告）日：2004-04-22

  This invention provides a method for initiation of farrowing of pregnant domestic swine within a predictable number of hours by administering a progesterone receptor antagonist. The present method also significantly reduces reduce stillborn pigs. A preferred progesterone receptor antagonist for use in the present method is RU38,486. The progesterone receptor antagonist can be administered to a pregnant swine via an appropriate route of administration, such as orally, intramuscularly or intravaginally. The present invention greatly facilitates human supervision and assistance during parturition, and is important for the production and profitability of farrowing operation.

  本发明提供了一种方法，通过使用孕酮受体拮抗剂，可在可预测的小时数内使怀孕家猪开始产仔。本方法还能大大减少死胎猪。用于本方法的首选孕酮受体拮抗剂是 RU38,486。孕酮受体拮抗剂可通过适当的给药途径，如口服、肌肉注射或阴道内给药给妊娠猪。本发明极大地方便了分娩过程中的人工监护和帮助，对产仔操作的生产和盈利具有重要意义。
• [EN] PROGESTERONE RECEPTOR ANTAGONISTS FOR REDUCING INCIDENCE OF STILLBORN PIGS<br/>[FR] ANTAGONISTES DU RECEPTEUR DE LA PROGESTERONE POUR REDUIRE LES INCIDENCE DES PORCS MORT-NES
  申请人：PFIZER PROD INC

  公开号：WO2004028543A1

  公开（公告）日：2004-04-08

  This invention provides a method for initiation of farrowing of pregnant domestic swine within a predictable number of hours by administering a progesterone receptor antagonist. The present method also significantly reduces stillborn pigs. A preferred progesterone receptor antagonist for use in the present method is RU38,486. The progesterone receptor antagonist can be administrated to a pregnant swine via an appropriate route of administration, such as orally, intramuscularly or intravaginally. The present invention greatly facilitates human supervision and assistance during parturition, and is important for the production and profitability of farrowing operation.