3-Hydroxy-10,13-dimethyl-17-(6-methyl-5-methylideneheptan-2-yl)-1,2,3,4,5,6,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-Hydroxy-10,13-dimethyl-17-(6-methyl-5-methylideneheptan-2-yl)-1,2,3,4,5,6,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• 化学式: C₂₈H₄₄O₂
• 分子量: 412.6
• InChiKey: XNNFSCUGVQFHNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Neural stem cells proliferation promoting agent
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2543380A1

  公开（公告）日：2013-01-09

  A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.

  一种神经干细胞增殖促进剂，其活性成分包括由青霉CND1007（FERM BP-10917）产生的化合物或其药学上可接受的盐；由青霉CND1007（FERM BP-10917）产生的新型化合物或其药学上可接受的盐；一种生产神经干细胞的方法，其包括培养神经干细胞，使其在青霉CND1007（FERM BP-10917）产生的化合物存在下增殖。CND1007或其药学上可接受的盐；一种生产神经干细胞的方法，该方法包括在青霉菌属CND1007产生的化合物或其药学上可接受的盐存在下培养神经干细胞以增殖神经干细胞，并从培养物中收获神经干细胞；等等。
• PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS
  申请人：Onodera Hideyuki

  公开号：US20110020931A1

  公开（公告）日：2011-01-27

  A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.