3-(3-(1H-imidazol-1-yl)propyl)-8-chloro-3H-pyrimido[5,4-b]indol-4(5H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 3-(3-(1H-imidazol-1-yl)propyl)-8-chloro-3H-pyrimido[5,4-b]indol-4(5H)-one
• 英文别名: 8-chloro-3-(3-imidazol-1-ylpropyl)-5H-pyrimido[5,4-b]indol-4-one
• 化学式: C₁₆H₁₄ClN₅O
• 分子量: 327.77
• InChiKey: KOWRHRIFOLXTHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK
  申请人：Scripps Health

  公开号：US20210187111A1

  公开（公告）日：2021-06-24

  Described herein are methods and compositions for disrupting a macrophage network. Described herein are targeting agents capable of targeting one or more cells of a macrophage network. Methods for treating various diseases, such as cancer and granulomatous diseases are provided.
• [EN] COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR PERTURBER UN RÉSEAU DE MACROPHAGES
  申请人：SCRIPPS HEALTH

  公开号：WO2020018434A1

  公开（公告）日：2020-01-23

  Described herein are methods and compositions for disrupting a macrophage network. Described herein are targeting agents capable of targeting one or more cells of a macrophage network. Methods for treating various diseases, such as cancer and granulomatous diseases are provided.