radulanin K | 132839-43-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: radulanin K
• 英文别名: 7-hydroxy-1a-methyl-5-(2-phenylethyl)-2,7b-dihydro-1H-cyclopropa[c]chromene-6-carboxylic acid
• CAS: 132839-43-1
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: MYGXJARNWKGOQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  radulanin K 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以11 mg的产率得到7-Methoxy-1a-methyl-5-phenethyl-1,1a,2,7b-tetrahydro-cyclopropa[c]chromene-6-carboxylic acid methyl ester
  参考文献：
  名称：

  Cyclopropanochroman derivatives from the liverwort Radula javanica

  摘要：

  Three new cyclopropanochromans, radulanins I, J and K were isolated from the liverwort Radula javanica, along with the previously known three prenyl bibenzyls, radulanins A and H, and 2-geranyl-3,5-dihydroxybibenzyl and a new cuparene-type sesquiterpenoid, (-)-2-(1,2,2-trimethyl)-cyclopentyl-6-methyl-1,4-quinone. The structures of the new compounds were 3-methyl-6-hydroxy-8-(2-phenylethyl)-3,5-cyclopropanochroman, 3-methyl-6-methoxy-8-(2-phenylethyl)-3,5-cyclopropanochroman and 3-methyl-6-hydroxy-7-carboxy-8-(2-phenylethyl)-3,5-cyclopropanochroman from their H-1 and C-13 NMR spectral data.

  DOI：

  10.1016/0031-9422(91)84147-k

文献信息

• ASAKAWA, YOSHINORI;KONDO, KEIKO;TORI, MOTOO, PHYTOCHEMISTRY, 30,(1991) N, C. 325-328
  作者：ASAKAWA, YOSHINORI、KONDO, KEIKO、TORI, MOTOO

  DOI：——

  日期：——
• Cyclopropanochroman derivatives from the liverwort Radula javanica
  作者：Yoshinori Asakawa、Keiko Kondo、Motoo Tori

  DOI：10.1016/0031-9422(91)84147-k

  日期：1991.1

  Three new cyclopropanochromans, radulanins I, J and K were isolated from the liverwort Radula javanica, along with the previously known three prenyl bibenzyls, radulanins A and H, and 2-geranyl-3,5-dihydroxybibenzyl and a new cuparene-type sesquiterpenoid, (-)-2-(1,2,2-trimethyl)-cyclopentyl-6-methyl-1,4-quinone. The structures of the new compounds were 3-methyl-6-hydroxy-8-(2-phenylethyl)-3,5-cyclopropanochroman, 3-methyl-6-methoxy-8-(2-phenylethyl)-3,5-cyclopropanochroman and 3-methyl-6-hydroxy-7-carboxy-8-(2-phenylethyl)-3,5-cyclopropanochroman from their H-1 and C-13 NMR spectral data.