1,2-bis(p-hydroxybenzoyloxy)-3-(4-hydroxyphenyl)dibenzofuran-4,7,8-triol | 1598414-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1,2-bis(p-hydroxybenzoyloxy)-3-(4-hydroxyphenyl)dibenzofuran-4,7,8-triol
• 英文别名: vialinin C；Vialinin C；[4,7,8-trihydroxy-1-(4-hydroxybenzoyl)oxy-3-(4-hydroxyphenyl)dibenzofuran-2-yl] 4-hydroxybenzoate
• CAS: 1598414-26-6
• 化学式: C₃₂H₂₀O₁₁
• 分子量: 580.504
• InChiKey: AHCMVVTZHBUTHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  187
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  1,2-bis(p-(benzyloxy)benzoyloxy)-7,8-bis(benzyloxy)-4-(benzyloxycarbonyloxy)-3-(4-(benzyloxy)phenyl)dibenzofuran 在 氢气 、 palladium(II) hydroxide 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 13.5h， 以86%的产率得到1,2-bis(p-hydroxybenzoyloxy)-3-(4-hydroxyphenyl)dibenzofuran-4,7,8-triol
  参考文献：
  名称：

  Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production

  摘要：

  A new inhibitor of TNF-alpha production (IC50 = 0.89 mu M) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.02.058

文献信息

• Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production
  作者：Yue Qi Ye、Chiemi Negishi、Yayoi Hongo、Hiroyuki Koshino、Jun-ichi Onose、Naoki Abe、Shunya Takahashi

  DOI：10.1016/j.bmc.2014.02.058

  日期：2014.4

  A new inhibitor of TNF-alpha production (IC50 = 0.89 mu M) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described. (C) 2014 Elsevier Ltd. All rights reserved.