cystochromone D

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: cystochromone D
• 英文别名: Cystochromone D；5-(8,14-dihydroxy-14-methyl-7-oxopentadecyl)-7-hydroxy-2-(2-hydroxypropyl)chromen-4-one
• 化学式: C₂₈H₄₂O₇
• 分子量: 490.637
• InChiKey: APDRBULCOHVYMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  cystochromone D 在 吡啶 、 4-二甲氨基吡啶 、 sodium methylate 、 N,N'-二异丙基碳二亚胺 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 142.0h， 生成
  参考文献：
  名称：

  Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium Cystobacter sp. MCy9104

  摘要：

  Seven new chromone-containing polyketides, termed cystochromones A-G, were isolated from the myxobacterial strain Cystobacter sp. MCy9104. Their structures were elucidated using comprehensive NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled substrate feeding experiments and NMR analysis suggested a hybrid iso-fatty acid and polyketide synthase biosynthetic pathway for these secondary metabolites.

  DOI：

  10.1021/acs.jnatprod.5b00343

文献信息

• Cystochromones, Unusual Chromone-Containing Polyketides from the Myxobacterium <i>Cystobacter</i> sp. MCy9104
  作者：Suvd Nadmid、Alberto Plaza、Ronald Garcia、Rolf Müller

  DOI：10.1021/acs.jnatprod.5b00343

  日期：2015.8.28

  Seven new chromone-containing polyketides, termed cystochromones A-G, were isolated from the myxobacterial strain Cystobacter sp. MCy9104. Their structures were elucidated using comprehensive NMR spectroscopy and HR-MS/MS. Cystochromones bear a pentadecyl moiety unusually attached at C-5 of the chromone ring. Moreover, isotope-labeled substrate feeding experiments and NMR analysis suggested a hybrid iso-fatty acid and polyketide synthase biosynthetic pathway for these secondary metabolites.