ethyl 7-chloro-2-oxo-4-phenyl-2H-chromene-3-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: ethyl 7-chloro-2-oxo-4-phenyl-2H-chromene-3-carboxylate
• 英文别名: Ethyl 7-chloro-2-oxo-4-phenyl-chromene-3-carboxylate；ethyl 7-chloro-2-oxo-4-phenylchromene-3-carboxylate
• 化学式: C₁₈H₁₃ClO₄
• 分子量: 328.752
• InChiKey: AZRLMGWCJSYTGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-2-甲氧基苯甲酸 在 aluminum (III) chloride 、 氯化亚砜 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N-二甲基甲酰胺 作用下， 反应 19.0h， 生成 ethyl 7-chloro-2-oxo-4-phenyl-2H-chromene-3-carboxylate
  参考文献：
  名称：

  Chlorinated Coumarins from the Polypore Mushroom Fomitopsis officinalis and Their Activity against Mycobacterium tuberculosis

  摘要：

  An EtOH extract of the polypore mushroom Fomitopsis officinalis afforded two new naturally occurring chlorinated coumarins, which were identified as the previously synthesized compounds 6-chloro-4-phenyl-2H-chromen-2-one (1) and ethyl 6-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (2). The structures of the two isolates were deduced by ab initio spectroscopic methods and confirmed by chemical synthesis. In addition, an analogue of each was synthesized as 7-chloro-4-phenyl-2H-chromen-2-one (3) and ethyl 7-chloro-2-oxo-4-phenyl-2H-chromen-3-carboxylate (4). All four compounds were characterized physicochemically, and their antimicrobial activity profiles revealed a narrow spectrum of activity with lowest MICs against the Mycobacterium tuberculosis complex.

  DOI：

  10.1021/np400497f

文献信息

• Integrative fungal solutions for protecting bees and overcoming colony collapse disorder (CCD)
  申请人：Stamets Paul Edward

  公开号：US10813960B2

  公开（公告）日：2020-10-27

  The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and mixtures of species, to provide an armamentarium of defenses from multiple stressors in order to help bees survive a complex of symptoms collectively called colony collapse disorder (CCD). More particularly, the present invention utilizes specific concentrations of extracts from pure cultured mycelium from mushroom forming fungi to reduce harmful viruses in bees and to increase the longevity of bees.

  本发明基于从单个真菌物种的菌丝体和物种混合物的提取物中获得的多种益处，提供了防御多种压力的武器，以帮助蜜蜂在被统称为蜂群崩溃紊乱症（CCD）的一系列症状中存活下来。更具体地说，本发明利用纯培养的蘑菇真菌菌丝体中特定浓度的提取物来减少蜜蜂体内的有害病毒，并延长蜜蜂的寿命。
• Integrative fungal solutions for protecting bees
  申请人：Stamets Paul E.

  公开号：US10821145B2

  公开（公告）日：2020-11-03

  The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and mixtures of species, to provide an armamentarium of defenses from multiple stressors in order to help bees survive a complex of symptoms collectively called colony collapse disorder (CCD). More particularly, the present invention utilizes specific concentrations of extracts from pure cultured mycelium from mushroom forming fungi to reduce harmful viruses in bees and to increase the longevity of bees.

  本发明基于从单个真菌物种的菌丝体和物种混合物的提取物中获得的多种益处，提供了防御多种压力的武器，以帮助蜜蜂在被统称为蜂群崩溃紊乱症（CCD）的一系列症状中存活下来。更具体地说，本发明利用从纯培养的蘑菇真菌菌丝体中提取的特定浓度的提取物来减少蜜蜂体内的有害病毒并延长蜜蜂的寿命。
• Psilocybin compositions
  申请人：Stamets Paul Edward

  公开号：US11471450B2

  公开（公告）日：2022-10-18

  Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

  本发明公开了使用真菌提取物及其有效成分（包括含有茜草素和茜草素的蘑菇种类和菌丝体），结合麦角苷和茜草素或含有这些有效成分的真菌提取物，并添加烟酸，来增强神经发生、解决神经病变和改善神经系统健康和功能的方法和组合物。组合物还可选择与神经性植物结合使用。
• INTEGRATIVE FUNGAL SOLUTIONS FOR PROTECTING BEES
  申请人：Stamets, Paul Edward

  公开号：EP3110260A1

  公开（公告）日：2017-01-04
• ANTIVIRAL ACTIVITY FROM MEDICINAL MUSHROOMS AND THEIR ACTIVE CONSTITUENTS
  申请人：Stamets, Paul Edward

  公开号：EP3277271A1

  公开（公告）日：2018-02-07