Pregnan-3-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Pregnan-3-ol
• 英文别名: 17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 化学式: C₂₁H₃₆O
• 分子量: 304.5
• InChiKey: CEBZORSAHLSRQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] ANTAGONISTS OF CB1 RECEPTOR.<br/>[FR] ANTAGONISTES DU RÉCEPTEUR CB1
  申请人：INST NAT SANTE RECH MED

  公开号：WO2012160006A1

  公开（公告）日：2012-11-29

  The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.

  本发明涉及CB1受体拮抗剂，用于治疗以下病理状况或疾病的成员组：膀胱和胃肠道疾病；炎症性疾病；心血管疾病；肾病；青光眼；痉挛性疾病；癌症；骨质疏松；代谢性疾病；肥胖症；成瘾、依赖、滥用和复发相关疾病；精神和神经疾病；神经退行性疾病；自身免疫性肝炎和脑炎；疼痛；生殖系统疾病和皮肤炎性和纤维化疾病。
• LIQUID CRYSTAL DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME
  申请人：Sony Corporation

  公开号：EP2385420A1

  公开（公告）日：2011-11-09

  A method of manufacturing a liquid crystal display device with which response characteristics are able to be easily improved without using major equipment is provided. The method of manufacturing a liquid crystal display device includes steps of forming a first alignment film 22 composed of a polymer compound having a crosslinkable functional group as a side chain on one substrate of a pair of substrates 20 and 30; forming a second alignment film 32 on the other substrate of the pair of substrates 20 and 30; arranging the pair of substrates 20 and 30 so that the first alignment film 22 and the second alignment film 32 are opposed to each other, and sealing a liquid crystal layer 40 containing a liquid crystal molecule 41 having negative dielectric constant anisotropy between the first alignment film 22 and the second alignment film 32; and bridging the polymer compound to give pretilt to the liquid crystal molecule 41 after sealing the liquid crystal layer 40.

  本发明提供了一种制造液晶显示装置的方法，该方法无需使用大型设备即可轻松改善响应特性。该液晶显示装置的制造方法包括以下步骤：在一对衬底 20 和 30 中的一个衬底上形成由具有可交联官能团作为侧链的聚合物化合物构成的第一配向膜 22；在一对衬底 20 和 30 中的另一个衬底上形成第二配向膜 32；将一对衬底 20 和 30 排列成第一配向膜 22 和第二配向膜 32 相对，并在第一配向膜 22 和第二配向膜 32 之间密封含有具有负介电常数各向异性的液晶分子 41 的液晶层 40；以及在密封液晶层 40 之后桥接聚合物化合物，使液晶分子 41 预倾斜。
• Compound for use in a photosensitive composition
  申请人：FUJIFILM Corporation

  公开号：EP2034361B1

  公开（公告）日：2012-02-01
• ANTAGONISTS OF CB1 RECEPTOR
  申请人：INSERM - Institut National de la Santé et de la Recherche Médicale

  公开号：EP2709631B9

  公开（公告）日：2017-07-26
• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI Bio, Inc.

  公开号：EP3229811B1

  公开（公告）日：2021-02-24