10,13-dimethyl-17-propan-2-yl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 10,13-dimethyl-17-propan-2-yl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 化学式: C₂₂H₃₆O
• 分子量: 316.5
• InChiKey: COSKITFSCAETCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Cell membrane-mimicking brush polymer and method for preparding same
  申请人：CEKO CO., LTD.

  公开号：US10907068B2

  公开（公告）日：2021-02-02

  The present invention relates to a cell membrane-mimicking brush polymer having surface properties mimicking a cell membrane and a self-assembly capability by means of a cell membrane mimicking functional group introduced to a brush terminal, and a method for preparing same.

  本发明涉及一种模拟细胞膜的刷状聚合物，它具有模拟细胞膜的表面特性，并且通过在刷状末端引入模拟细胞膜的官能团而具有自组装能力，本发明还涉及一种制备方法。
• Cell Membrane-Mimicking Brush Polymer And Method For Preparding Same
  申请人：CEKO CO., LTD.

  公开号：US20190276701A1

  公开（公告）日：2019-09-12

  The present invention relates to a cell membrane-mimicking brush polymer having surface properties mimicking a cell membrane and a self-assembly capability by means of a cell membrane mimicking functional group introduced to a brush terminal, and a method for preparing same.
• DOCK1-INHIBITING COMPOUND AND USE THEREOF
  申请人：KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

  公开号：US20220017486A1

  公开（公告）日：2022-01-20

  Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably provided is a compound that has DOCK1-inhibiting activity and exerts an anticancer effect based on the activity. A compound represented by the following formula (A) or a salt thereof: wherein X represents a carbon atom or a nitrogen atom; Y represents an oxygen atom, a hydroxy group, or a hydrocarbon group; R 1 and R 2 are different, and each represents a hydrogen atom or a group represented by the following formula (A-1): (wherein R 6 represents a pyrrolidino group or a phenyl group, and n 2 is 0 or 1); R 3 represents —CO—R 7 (wherein R 7 is an alkoxy group, an alkyl group, or an alkylamino group), a 1,3-oxazole group, an alkylhydroxy group, a hydrogen atom, or an oxygen atom; R 4 represents a hydrogen atom, an oxygen atom, or a hydrocarbon group in which one or more hydrogen atoms may be replaced by one or more substituents; R 5 represents a halogen atom, a halogenated alkyl group, or a halogenated alkylthio group; and n 1 is an integer of 0 to 5; and in the skeleton of the compound of formula (A), each single solid line represents a single bond; each double line consisting of a solid line and a dotted line represents a single bond or a double bond; and two dotted lines represent no bond or a double bond.