Acovenoside A | 663-95-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Acovenoside A
• 英文别名: 3-[3-(3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-1,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
• CAS: 663-95-6
• 化学式: C₃₀H₄₆O₉
• 分子量: 550.7
• InChiKey: DKYDBQQIQAPGMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  39
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  T
• 危险类别码：
  R23/24/25
• 危险品运输编号：
  UN 3172
• 包装等级：
  III
• 危险类别：
  6.1(b)

文献信息

• Methods of inhibiting leaderless protein export using cardiac glycosides and derivatives
  申请人：The Scripps Research Institute

  公开号：EP0941733A2

  公开（公告）日：1999-09-15

  This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1α, IL-1β and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.

  本发明提供了通过使细胞与强心苷或苷元衍生物接触来抑制无领导蛋白从细胞中输出的方法。无领导蛋白包括 FGF-1、FGF-2、IL-1α、IL-1β 和因子 XIIIa。这些方法可用于治疗各种疾病，包括肿瘤和糖尿病。
• Method of increasing satellite cell proliferation with an HDAC inhibitor
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10660902B2

  公开（公告）日：2020-05-26

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

  本发明提供了诱导、增强或增加卫星细胞增殖的方法，以及用于筛选诱导、增强或增加卫星细胞增殖的候选化合物的检测方法。本发明还提供了修复或再生受试者受损肌肉组织的方法。
• Small molecules for mouse satellite cell proliferation
  申请人：President and Fellows of Harvard College

  公开号：US11026952B2

  公开（公告）日：2021-06-08

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

  本发明提供了诱导、增强或增加卫星细胞增殖的方法，以及用于筛选诱导、增强或增加卫星细胞增殖的候选化合物的检测方法。本发明还提供了修复或再生受试者受损肌肉组织的方法。
• Natural compounds and fibrosis
  申请人：MEDIZINISCHE HOCHSCHULE HANNOVER (MHH)

  公开号：US11185539B2

  公开（公告）日：2021-11-30

  The present invention relates to an inhibitor of miR-671-5p for use in a method of preventing or treating fibrosis. Further, the present invention encompasses a kit comprising said inhibitor of miR-671-5p. The present invention also relates to an in vitro method for identifying a compound for preventing or treating fibrosis.

  本发明涉及一种用于预防或治疗纤维化方法的 miR-671-5p 抑制剂。此外，本发明还包括一种包含所述 miR-671-5p 抑制剂的试剂盒。本发明还涉及一种用于鉴定预防或治疗纤维化的化合物的体外方法。
• Cardiac glycosides for treating muscle pain and spasm
  申请人：——

  公开号：US20030229029A1

  公开（公告）日：2003-12-11

  This invention provides methods of treating muscle spasm and/or pain by treatment with a cardiac glycoside or aglycone derivative. These methods are useful in treatment of conditions associated with muscle pain.

  本发明提供了用强心苷或苷元衍生物治疗肌肉痉挛和/或疼痛的方法。这些方法可用于治疗与肌肉疼痛相关的疾病。