Bipyridine, dihydro- | 64534-28-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Bipyridine, dihydro-
• 英文别名: 2-(1,2-dihydropyridin-2-yl)pyridine
• CAS: 64534-28-7
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.2
• InChiKey: ZITSIOCNMCGZQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20160280701A1

  公开（公告）日：2016-09-29

  Biheteroaryl dicarboxylates and esters, and salts thereof which are useful as modulators of CP4H activity and more particularly as inhibitors of CP4H. Compounds of formula: and salts thereof where: X is S, O, NH, or NR, where R is an alkyl group having 1-3 carbon atoms; R 1 and R 2 independently are —OR 7 , or —NHSO 2 R 8 , where R 7 is selected from: hydrogen, alkyl, alkenyl, alkoxyalkyl, —R′—CO—R″, —R′—CO—O—R″, —CO—R″, —R′—O—CO—R″, —R′—CO—NR″, —CO—NR″, or —R′—O—CO—NR″, and R 8 is selected from hydrogen, alkyl, aryl, arylalkyl; R 3 , R 4 and R 6 independently are hydrogen, alkyl, alkoxy, alkenyl, alkenoxy, halo alkyl, haloalkenyl, halogen, hydroxyl, hydroxyalkyl, hydroxyalkenyl, aryl, aryloxy, arylalkyl or arylalkyloxy; R 5 is hydrogen, halogen, alkyl having 1-3 carbon atoms, or alkoxy having 1-3 carbon atoms; —R′— is a divalent straight chain or branched alkylene, and —R″ is an alkyl, alkenyl, arylalkyl, or aryl group. Methods for inhibition of CP4H in vivo and in vitro.

  Biheteroaryl二羧酸酯和酯，以及它们的盐，可用作CP4H活性的调节剂，更具体地作为CP4H的抑制剂。化合物的结构式:及其盐，其中:X为S、O、NH或NR，其中R为具有1-3个碳原子的烷基基团；R1和R2独立地为—OR7，或—NHSO2R8，其中R7选自：氢、烷基、烯基、烷氧基烷基、—R′—CO—R″、—R′—CO—O—R″、—CO—R″、—R′—O—CO—R″、—R′—CO—NR″、—CO—NR″或—R′—O—CO—NR″，而R8选自氢、烷基、芳基、芳基烷基；R3、R4和R6独立地为氢、烷基、烷氧基、烯基、烯氧基、卤代烷基、卤代烯基、卤素、羟基、羟基烷基、羟基烯基、芳基、芳氧基、芳基烷基或芳基烷氧基；R5为氢、卤素、具有1-3个碳原子的烷基，或具有1-3个碳原子的烷氧基；—R′—为二价的直链或支链烷基，而—R″为烷基、烯基、芳基烷基或芳基。用于体内和体外抑制CP4H的方法。
• COPOLYMER COMPOSITIONS AND USES THEREOF
  申请人：ETH Zurich

  公开号：EP3093027A1

  公开（公告）日：2016-11-16

  The present invention is directed to non-biodegradable copolymer diagnosis agent that has a low affinity for the mucosa in general and allows the transportation of specific molecules that recognizes specific target biomarkers useful in the diagnosis of a certain number of disorders such as pulmonary, gynecologic, eye and gastrointestinal diseases or disorders, and certain conditions of those diseases (such as fibrosis and inflammation), in particular inflammatory bowel disease, such as Crohn's disease or ulcerative colitis (UC) as well as coeliac disease and cancers such as colorectal cancers.

  本发明涉及一种非生物降解共聚物诊断试剂，其对粘膜的亲和力较低，可以运输识别特定靶标生物标志物的特定分子，用于诊断一定数量的疾病或疾病的特定情况，例如肺部、妇科、眼部和胃肠道疾病或疾病，以及这些疾病的某些情况（例如纤维化和炎症），特别是炎症性肠病，如克罗恩病或溃疡性结肠炎（UC），以及乳糜泻和结直肠癌等癌症。
• ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP2645443A1

  公开（公告）日：2013-10-02

  An organic electroluminescence device including an anode, an emitting layer, a blocking layer, an electron-injecting layer and a cathode in this sequence, the emitting layer including a host and a styrylamine derivative having a specific structure; and the triplet energy ETb of the blocking layer being larger than the triplet energy ETh of the host

  一种有机电致发光器件，包括依次排列的阳极、发射层、阻挡层、电子注入层和阴极，发射层包括宿主和具有特定结构的苯乙烯胺衍生物；阻挡层的三重能 ETb 大于宿主的三重能 ETh
• COMPOSITION FOR GEL POLYMER ELECTROLYTE AND LITHIUM SECONDARY BATTERY COMPRISING SAME
  申请人：LG Chem, Ltd.

  公开号：EP2790260B1

  公开（公告）日：2016-03-23
• METAL-BASED THIOPHENE PHOTODYNAMIC COMPOUNDS AND THEIR USE
  申请人：McFarland, Sherri Ann

  公开号：EP2854948B1

  公开（公告）日：2019-09-25