Luteoskyrin accumulates selectively in the liver, with minor distribution to the serum and kidneys. In the liver it is reduced to its semiquinone radical by NADPH-dependent cytochrome reductases. (A3070,A3071)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
毒性总结
Luteoskyrin 对肝脏有毒。人们认为这是由于它在肝脏中被 NADPH 依赖性细胞色素还原酶催化代谢还原为半醌自由基，导致在氧化还原系统中产生活性氧种。这会引起脂质过氧化、肝细胞膜损伤和血清转氨酶活性升高，从而导致肝脏损伤。Luteoskyrin 还具有肝致癌性，可能是由于其能诱导 DNA 断裂的能力。它能够与 DNA 结合，与核酸和选择的金属离子形成螯合物。Luteoskyrin 抑制 DNA 的复制、转录和修复，这至少部分是因为它抑制了 RNA 聚合酶和核糖核酸酶 H。(A2955, A3042, A3070, A3071, A3072)
Luteoskyrin is hepatotoxic. It is thought that this is a result of its metabolic reduction to the semiquinone radical catalyzed by NADPH-dependent cytochrome reductases in the liver, leading to the generation of active oxygen species in redox systems. This causes the induction of lipid peroxidation, hepatocellular membrane damage, and elevation of serum transaminase activities, resultin in liver injuries. Luteoskyrin is also hepatocarcinogenic, possibly a result of its ability to induce DNA fragmentation. It is able to bind to DNA, forming chelate-complexes with nucleic acids and select metal ions. Luteoskyrin inhibits the replication, transcription and repair of DNA, which is at least partially because it inhibits RNA polymerase and ribonuclease H. (A2955, A3042, A3070, A3071, A3072)
来源:Toxin and Toxin Target Database (T3DB)
毒理性
致癌性证据
没有关于人类的数据。动物致癌性的证据有限。总体评估：第3组：该物质对人类致癌性无法分类。
No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
国际癌症研究机构致癌剂：杂色曲霉素
IARC Carcinogenic Agent:Luteoskyrin
来源:International Agency for Research on Cancer (IARC)
毒理性
致癌物分类
国际癌症研究机构（IARC）致癌物分类：第3组：无法归类其对人类致癌性
IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans
来源:International Agency for Research on Cancer (IARC)
毒理性
致癌物分类
国际癌症研究机构专著：第10卷：（1976年）一些天然存在的物质
IARC Monographs:Volume 10: (1976) Some Naturally Occurring Substances
来源:International Agency for Research on Cancer (IARC)
...IS ABSORBED SLOWLY FOLLOWING ITS SC (3 DAILY INJECTIONS OF 5 UG/G) OR ORAL ADMIN (9 UG/ANIMAL) /OF (3)H-LUTEOSKYRIN/. RADIOACTIVITY WAS EXTREMELY HIGH IN THE LIVER WHEN COMPARED WITH THAT IN OTHER ORGANS... LUTEOSKYRIN WAS EXCRETED VIA THE BILE AND KIDNEYS, AS SHOWN BY CHEMICAL IDENTIFICATION OF LUTEOSKYRIN IN THE FECES AND URINE.
