4-(3-acetyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-(3-acetyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
• 化学式: C₂₆H₄₂O₄
• 分子量: 418.6
• InChiKey: FCQRLHQHKFKTQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TANDEM FACIAL AMPHIPHILES
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20150011739A1

  公开（公告）日：2015-01-08

  The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display favorable behavior with several membrane proteins. These amphiphiles can form relatively small micelles, and small changes in amphiphile chemical structures can result in large changes in their physical properties. The tandem facial amphiphiles can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.

  该发明提供了串联面部两性分子，用于生物化学操作和膜蛋白质的表征，例如内在膜蛋白质。这个新家族的成员与几种膜蛋白质表现出良好的行为。这些两性分子可以形成相对较小的胶束，两性分子化学结构的微小变化可以导致它们的物理性质发生大的变化。串联面部两性分子可用于辅助膜蛋白质的溶解、分离、纯化、稳定、结晶和/或结构确定。
• Tandem facial amphiphiles
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US10316057B2

  公开（公告）日：2019-06-11

  The invention provides tandem facial amphiphiles for biochemical manipulations and characterization of membrane proteins, such as intrinsic membrane proteins. Members of this new family display favorable behavior with several membrane proteins. These amphiphiles can form relatively small micelles, and small changes in amphiphile chemical structures can result in large changes in their physical properties. The tandem facial amphiphiles can be used to aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.

  本发明提供了串联面部双亲化合物，用于膜蛋白（如固有膜蛋白）的生化操作和表征。这一新家族的成员对多种膜蛋白具有良好的作用。这些双亲化合物可形成相对较小的胶束，双亲化合物化学结构的微小变化可导致其物理性质的巨大变化。串联面部双亲化合物可用于帮助膜蛋白的增溶、分离、纯化、稳定、结晶和/或结构测定。
• US8815263B2
  申请人：——

  公开号：US8815263B2

  公开（公告）日：2014-08-26