19-Hydroxy-pregnen-(4)-dion-(3.20) | 596-63-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 19-Hydroxy-pregnen-(4)-dion-(3.20)
• 英文别名: 3,20-Dioxo-19-hydroxy-4-pregnen；19-Hydroxyprogesteron；17-Acetyl-10-(hydroxymethyl)-13-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 596-63-4；102628-36-4
• 化学式: C₂₁H₃₀O₃
• 分子量: 330.467
• InChiKey: FIHWBGCIKMXLBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) for treating excess of glucocorticoids
  申请人：——

  公开号：US20040029846A1

  公开（公告）日：2004-02-12

  The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of diseases associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues having the formula FORMULAwherein X is S, SO and SO2, and R is either M or OH, for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues. 1

  本发明涉及新型21-羟基-6,19-氧代孕酮（21OH-6OP）类似物，其用作抗糖皮质激素治疗和/或预防与糖皮质激素过量相关的疾病。具体来说，本发明涉及使用具有以下公式的新型21-羟基-6,19-氧代孕酮（21OH-6OP）类似物，其中X为S、SO和SO2，R为M或OH，用于治疗库欣综合征、医源性高皮质醇血症或抑郁症。此外，本发明还涉及制备新型21-羟基-6,19-氧代孕酮（21OH-6OP）类似物的方法。
• SULPHUR ANALOGUES OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP) FOR TREATING EXCESS OF GLUCOCORTICOIDS
  申请人：Applied Research Systems ARS Holding S.A.

  公开号：EP1330468A1

  公开（公告）日：2003-07-30
• US7053228B2
  申请人：——

  公开号：US7053228B2

  公开（公告）日：2006-05-30
• [EN] SULPHUR ANALOGUES OF 21-HYDROXY-6,19-OXIDOPROGESTERONE (21OH-6OP) FOR TREATING EXCESS OF GLUCOCORTICOIDS<br/>[FR] ANALOGUES SOUFRES DE 21-HYDROXY-6,19-OXYDOPROGESTERONE (21OH-6OP) PERMETTANT DE TRAITER L'EXCES DE GLUCOCORTICOIDES
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2002022647A1

  公开（公告）日：2002-03-21

  The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of diseases associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues having the formula FORMULAwherein X is S, SO and SO2, and R is either H or OH, for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.