Sterol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Sterol
• 英文别名: 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 化学式: C₁₇H₂₈O
• 分子量: 248.4
• InChiKey: FPXSXMFOYWRHDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• POLYMER-CARBOHYDRATE CONJUGATES FOR DRUG DELIVERY TECHNOLOGY
  申请人：Wu Nian

  公开号：US20150157721A1

  公开（公告）日：2015-06-11

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  该发明包括化合物、制备方法和使用方法。这些化合物可能具有线性或环状的骨架，以及三个或四个附加的功能基团：一个或两个疏水化合物，包括固醇或“脂溶性”维生素，一个或两个亲水性聚合物，以及一个或两个碳水化合物。公开了一组具有中心骨架和三个附加功能基团的聚合物-碳水化合物共轭物，其中一个疏水性化合物不含类固醇酸。该共轭物可能以脂肪酸作为主要疏水载体，一个亲水性聚合物和一个碳水化合物。特定的功能基团可以根据在制备药物、化妆品、营养保健品等方面的具体应用而选择。共轭物的典型偶联反应可能涉及一种或多种或组合或串联的烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化化学过程。还可以选择各种连接剂连接骨架和功能基团之间，以修改载体或中心骨架以进行偶联反应并优化共轭物的性能。
• [EN] LIPOCATIONIC POLYMERS AND USES THEREOF<br/>[FR] POLYMÈRES LIPOCATIONIQUES ET LEURS UTILISATIONS
  申请人：UNIV TEXAS

  公开号：WO2016094342A1

  公开（公告）日：2016-06-16

  Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

  通过环氧聚合产生的聚合物，其中包含可以用于将核酸如miRNA或siRNA传递到组合物中的氨基团。在某些实施例中，还提供了包括所述聚合物和核酸的组合物。在某些实施例中，这些组合物被用于在体内沉默一个或多个基因或治疗疾病或紊乱。
• [EN] LIPOCATIONIC DENDRIMERS AND USES THEREOF<br/>[FR] DENDRIMÈRES LIPOCATIONIQUES ET LEURS UTILISATIONS
  申请人：UNIV TEXAS

  公开号：WO2017048789A1

  公开（公告）日：2017-03-23

  Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

  本文提供了带有阳离子基团和亲脂基团的模块化树状聚合物。在某些方面，本文提供的树状聚合物可以配制成含有核酸和一个或多个辅助赋形剂的组合物。在某些方面，这些组合物也可以用于治疗含有治疗性核酸的疾病或疾患。
• [EN] CATIONIC SULFONAMIDE AMINO LIPIDS AND AMPHIPHILIC ZWITTERIONIC AMINO LIPIDS<br/>[FR] LIPIDES SULFONAMIDE AMINÉS CATIONIQUES ET LIPIDES AMINÉS ZWITTERIONIQUES AMPHIPHILES
  申请人：UNIV TEXAS

  公开号：WO2017201076A1

  公开（公告）日：2017-11-23

  The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: Formula (I) or (IV) wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

  本公开提供一种或多种氨基脂质，例如含有磺酸或磺酸衍生物的氨基脂质，其化学式为：化学式（I）或（IV），其中变量如本文所定义。这些氨基脂质可以与一种或多种辅助脂质和核酸治疗剂组成配方。这些配方可用于治疗癌症、囊性纤维化或其他遗传疾病等疾病或紊乱。
• [EN] BIAMINOQUINOLINES AND NANOFORMULATIONS FOR CANCER TREATMENT<br/>[FR] BIAMINOQUINOLINES ET NANOFORMULATIONS POUR LE TRAITEMENT DU CANCER
  申请人：UNIV CALIFORNIA

  公开号：WO2021055705A1

  公开（公告）日：2021-03-25

  The present invention provides bisaminoquinoline compounds of Formula (I). The present invention also provides nanocarriers comprising compounds of the present invention, and methods of using the nanocarriers for treating diseases and imaging.

  本发明提供了式（I）的双氨基喹啉化合物。本发明还提供了包含本发明化合物的纳米载体，以及利用这些纳米载体用于治疗疾病和成像的方法。