estramustine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: estramustine
• 英文别名: Emcyt；(17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) N,N-bis(2-chloroethyl)carbamate
• 化学式: C₂₃H₃₁Cl₂NO₃
• 分子量: 440.41
• InChiKey: FRPJXPJMRWBBIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds and pharmaceutical compositions for the treatment of liver disorders
  申请人：Sommadossi Jean-Pierre

  公开号：US20080261913A1

  公开（公告）日：2008-10-23

  Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
• [EN] COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LIVER DISORDERS<br/>[FR] COMPOSES ET COMPOSITIONS PHARMACEUTIQUES DESTINES AU TRAITEMENT DES TROUBLES HEPATIQUES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2008082602A2

  公开（公告）日：2008-07-10

  [EN] Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
  [FR] L'invention concerne des composés, des compositions et des méthodes de traitement des troubles hépatiques, notamment du cancer du foie et des maladies métaboliques telles que le diabète, l'hyperlipidémie, l'athérosclérose et l'obésité. L'invention concerne en particulier des composés et des compositions de dérivés de nucléosides pouvant être administrés seuls ou associés à d'autres agents anticancéreux.