2-[2-[[Bis(pyridin-2-ylmethyl)amino]methyl]phenyl]-3',6'-bis(diethylamino)spiro[isoindole-3,9'-xanthene]-1-one | 1256372-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[2-[[Bis(pyridin-2-ylmethyl)amino]methyl]phenyl]-3',6'-bis(diethylamino)spiro[isoindole-3,9'-xanthene]-1-one
• 英文别名: 2-[2-[[bis(pyridin-2-ylmethyl)amino]methyl]phenyl]-3',6'-bis(diethylamino)spiro[isoindole-3,9'-xanthene]-1-one
• CAS: 1256372-58-3
• 化学式: C₄₇H₄₈N₆O₂
• 分子量: 728.937
• InChiKey: RTTSCHDREFPRSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  55
• 可旋转键数：
  13
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  65
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(9-(2-(chlorocarbonyl)phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)-N-ethylethanaminium chloride 、 2-[bis(2-pyridylmethyl)aminomethyl]aniline 在 三乙胺 作用下， 以 乙腈 为溶剂， 以400 mg的产率得到2-[2-[[Bis(pyridin-2-ylmethyl)amino]methyl]phenyl]-3',6'-bis(diethylamino)spiro[isoindole-3,9'-xanthene]-1-one
  参考文献：
  名称：

  A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells

  摘要：

  We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Cd2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels.

  DOI：

  10.1021/ic101569a

文献信息

• A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells
  作者：Pingwu Du、Stephen J. Lippard

  DOI：10.1021/ic101569a

  日期：2010.12.6

  We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Cd2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels.