3-Pregnanon | 1474-66-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-Pregnanon
• 英文别名: Pregnanon-3；5α-Pregnan-3-on；(10S,13R,17S)-17-ethyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
• CAS: 1474-66-4；14778-11-1；95340-28-6
• 化学式: C₂₁H₃₄O
• 分子量: 302.5
• InChiKey: JMAPHBFIBIHSIT-RCNYTBCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• FRAGRANCE COMPOSITIONS AND OTHER COMPOSITIONS WHICH CONTAIN NATURALLY OCCURRING SUBSTANCES FOUND IN CORALS
  申请人：JENNINGS-WHITE Chloe

  公开号：US20090075964A1

  公开（公告）日：2009-03-19

  This invention is generally related to the fields of fragrance compositions, personal care products, and home consumer products. This invention also relates to 20-pregnenes, in particular those found naturally occurring in corals and which affect mood in humans, to the incorporation of these 20-pregnene compounds into various compositions, and to methods of affecting the mood of individuals using such compounds.

  这项发明通常与香精配方、个人护理产品和家用消费品领域相关。该发明还涉及20-孕烯类化合物，特别是那些在珊瑚中自然存在且对人类情绪产生影响的化合物，将这些20-孕烯类化合物纳入各种配方中，以及利用这些化合物影响个体情绪的方法。
• Process for the preparation of pregnane derivatives
  申请人：——

  公开号：US20030181742A1

  公开（公告）日：2003-09-25

  A process for preparing pregnane derivatives represented by the formula (V), 1 which comprises the steps of: reacting an alkali (earth) metal with a compound represented by the formula (I) 2 in the presence of ammonia or an amine, to obtain a compound represented by the formula (II); 3 protecting the hydroxy groups of the obtained compound, to obtain a compound represented by the formula (III); 4 protecting the 3-position carbonyl group of the obtained compound, to obtain a compound represented by the formula (IV); 5 and subjecting the obtained compound to solvolysis; and the compound (II).

  一种制备以公式（V）表示的孕烷衍生物的方法，包括以下步骤：在氨或胺的存在下，将以公式（I）表示的化合物与碱金属（碱土金属）反应，得到以公式（II）表示的化合物；保护所得化合物的羟基，得到以公式（III）表示的化合物；保护所得化合物的3位置羰基基团，得到以公式（IV）表示的化合物；将所得化合物进行溶剂解离反应；以及化合物（II）。
• Steroid-Derived Pharmaceutical Compositions
  申请人：Braxmeier Tobias

  公开号：US20080255076A1

  公开（公告）日：2008-10-16

  The present invention relates to the use of specific steroid derivatives in the preparation of medicaments for the treatment or prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.