Conessin | 1192249-43-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Conessin
• 英文别名: Neriine；N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.02,9.05,9.013,18]icos-18-en-16-amine
• CAS: 1192249-43-6
• 化学式: C₂₄H₄₀N₂
• 分子量: 356.595
• InChiKey: GPLGAQQQNWMVMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Steroidal compounds as melanogenesis modifiers and uses thereof
  申请人：Orlow Seth J.

  公开号：US20100040568A1

  公开（公告）日：2010-02-18

  Provided are steroidal compounds of formula I, for example, conessine, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. Also provided are plant extracts containing a compound of formula I, for example, conessine, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.
• STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF
  申请人：Orlow Seth J.

  公开号：US20100093823A1

  公开（公告）日：2010-04-15

  A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.
• [EN] STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF<br/>[FR] COMPOSÉS STÉROÏDIENS EN TANT QUE MODIFICATEURS DE MÉLANOGÉNÈSE ET LEURS UTILISATIONS
  申请人：NEW YORK UNIVERSITY OF SCHOOL

  公开号：WO2009134404A2

  公开（公告）日：2009-11-05

  A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: Me I The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.
• [EN] STEROIDAL COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF<br/>[FR] COMPOSÉS STÉROÏDES EN TANT QUE MODIFICATEURS DE LA MÉLANOGENÈSE ET LEURS UTILISATIONS
  申请人：UNIV NEW YORK

  公开号：WO2011046978A2

  公开（公告）日：2011-04-21

  Provided are steroidal compounds of formula I, for example, conessine, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. Also provided are plant extracts containing a compound of formula I, for example, conessine, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.