4-[2-[[3-(3-Hydroxyphenyl)-2-methylpropyl]amino]ethyl]benzene-1,2-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[2-[[3-(3-Hydroxyphenyl)-2-methylpropyl]amino]ethyl]benzene-1,2-diol
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.4
• InChiKey: GUTBEOXGILVYQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS
  申请人：Eisenberg David S.

  公开号：US20100048510A1

  公开（公告）日：2010-02-25

  Methods for disrupting amyloid fibrils in a subject, comprising combining an effective amount of a β-2 microglobulin fibril disrupting compound with a medium associated with the subject, are disclosed. The invention also relates to combining the β-2 microglobulin fibril disrupting compound ex vivo with the blood during dialysis treatment of an animal. It also relates to methods for determining which compounds are effective at disrupting amyloid fibrils in a medium.
• US9463195B2
  申请人：——

  公开号：US9463195B2

  公开（公告）日：2016-10-11