WS79089A | 157110-23-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: WS79089A
• 英文别名: 3,13,19,26-Tetrahydroxy-15-methoxy-7-methyl-6-oxahexacyclo[12.12.0.02,11.04,9.016,25.018,23]hexacosa-1(14),2(11),3,9,15,18(23),19,21,25-nonaene-5,17,24-trione
• CAS: 157110-23-1
• 化学式: C₂₇H₂₀O₉
• 分子量: 488.45
• InChiKey: HRWPMELFEHBAIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  36
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  WS79089A 在 氢化铝钠 、 sodium hydrogensulfite 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以30%的产率得到7,10,14,16-Tetrahydroxy-3-methyl-3,4,6,7-tetrahydro-2-oxa-hexaphene-1,8,15-trione
  参考文献：
  名称：

  Synthesis of a New Polycyclic Quinone by Reduction of a Dihydrobenzo[a]naphthacenequinone.

  摘要：

  DOI：

  10.7164/antibiotics.54.191

文献信息

• WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
  作者：YASUHISA TSURUMI、NOBUTAKA OHHATA、TOSHIRO IWAMOTO、NOBUHARU SHIGEMATSU、KAZUTOSHI SAKAMOTO、MOTOAKI NISHIKAWA、SUMIO KIYOTO、MASAKUNI OKUHARA

  DOI：10.7164/antibiotics.47.619

  日期：——

  WS79089A, B and C, which are novel endothelin converting enzyme (ECE) inhibitors have been isolated from the fermentation broth of Streptosporangium roseum No. 79089. These inhibitors were purified from an acetone extract of whole culture broth followed by Silicar CC-4 column chromatography and HPLC. WS79089A, B and C showed highly selective ECE inhibition activity with IC50 values of 0.73μM 0.14μM and 3.42μM, respectively. On the basis of spectroscopic and chemical evidence, the tentative structures of WS79089A, B and C have been proposed, they have benzo[a]naphtacen chromophores.
• Synthesis of a New Polycyclic Quinone by Reduction of a Dihydrobenzo[a]naphthacenequinone.
  作者：UTA FERNEKORN、THOMAS HEINZE、BRIGITTE SCHLEGEL、HANS-MARTIN DAHSE、UDO GRÄFE

  DOI：10.7164/antibiotics.54.191

  日期：——