3-(2'-hydroxyphenyl)-2-hydroxypropanoic acid | 6803-09-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(2'-hydroxyphenyl)-2-hydroxypropanoic acid
• 英文别名: o-Hydroxyphenyllactic acid；2-hydroxy-3-(2-hydroxyphenyl)propanoic acid；3-(2-hydroxyphenyl)-lactic acid；2-hydroxy-3-(2-hydroxy-phenyl)-propionic acid；2-Hydroxy-3-(2-hydroxy-phenyl)-propionsaeure；α-Oxy-β-(2-oxy-phenyl)-propionsaeure
• CAS: 6803-09-4
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: HXQBZGMVGIDZAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  127-128 °C
• 沸点：
  396.8±27.0 °C(Predicted)
• 密度：
  1.404±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 3-(2'-hydroxyphenyl)-2-hydroxypropanoic acid 以 甲醇 、 乙醚 为溶剂， 反应 1.0h， 以4 mg的产率得到methyl 2-hydroxy-3-(2-hydroxyphenyl)propanoate
  参考文献：
  名称：

  Novel Antioxidant Compounds from Tart Cherries (Prunus cerasus)

  摘要：

  As indicated by an Fe(II)-induced liposome peroxidation bioassay, the EtOAc extract of tart cherries (Prunus cerasus) was found to have strong antioxidant activity. Purification of this extract afforded chlorogenic acid methyl ester (1) and three novel compounds, 2-hydroxy-3-(o-hydroxyphenyl) propanoic acid (2); 1-(3',4'-dihydroxycinnamoyl)-cyclopenta- 2,5 -diol (3), and 1-(3',4'-dihydroxycinnamoyl)-cyclopenta-2,3-diol (4), as determined by their spectral data. At a 20-mu M concentration, the antioxidant activities of compounds 3 and 4 were comparable to the antioxidant activities of caffeic acid, whereas compound 1 showed activity similar to chlorogenic acid. Also, these compounds showed antioxidant activities similar to the commercial antioxidants tert-butylhydroquinone and butylated hydroxytoluene. However, compound 2 was not active when tested at a 100-mu M concentration.

  DOI：

  10.1021/np980268s
• 作为产物：
  描述：

  3-乙酰氨基香豆素 在 sodium hydroxide 、 sodium amalgam 作用下， 生成 3-(2'-hydroxyphenyl)-2-hydroxypropanoic acid
  参考文献：
  名称：

  Synthesis of o-Tyrosine and Related Phenolic Acids¹

  摘要：

  DOI：

  10.1021/jo01112a001

文献信息

• PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF
  申请人：Mickle Travis

  公开号：US20110002991A1

  公开（公告）日：2011-01-06

  The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前描述的技术提供苯乙酸、苯丙酸、苯丙烯酸、其盐、其衍生物或其化学结合到羟考酮（吗啡酮-6-酮，4,5-α-环氧-3-甲氧基-17-甲基）以形成新型羟考酮的前药或组合物，其具有降低滥用羟考酮的潜力。该技术还提供了治疗患者的方法、药物配套和合成本技术结合物的方法。
• [EN] 2-((5-(PHENYL)-PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)AMINO)-3-(PHENYL)PROPANOIC ACID DERIVATIVES AND RELATED COMPOUNDS AS MCL-1 ENZYME INHIBITORS FOR TREATING CANCER<br/>[FR] DÉRIVÉS D'ACIDE 2-((5-(PHÉNYL)-PYRROLO[2,1-F][1,2,4]TRIAZIN-4-YL)AMINO)-3-(PHÉNYL)PROPANOÏQUE ET COMPOSÉS APPARENTÉS SERVANT D'INHIBITEURS D'ENZYME MCL-1 POUR LE TRAITEMENT DU CANCER
  申请人：PRELUDE THERAPEUTICS INC

  公开号：WO2020123994A1

  公开（公告）日：2020-06-18

  A compound of formula I (the variables are defined in the claims) or a pharmaceutically acceptable salt or solvate thereof, as an MCL-1 enzyme inhibitor for treating colon cancer, breast cancer, small-cell lung cancer, non-small- cell lung cancer, bladder cancer, ovarian cancer, prostate cancer, chronic lymphoid leukemia, lymphoma, myeloma, acute myeloid leukemia, or pancreatic cancer. The present description discloses the synthesis of exemplary compounds as well as biological assays thereof (e.g. pages 55 to 114; paragraphs [00216] to [00304]; examples 1 to 33; tables A and 2). An exemplary compound is e.g. (2R)-2-[(5Ra)-5-3-chloro-2-methyl-4-[2-(4-methylpiperazin-l-yl) ethoxy]phenyl}-6-(4-fluorophenyl) py rrolo[2, l-f][l, 2, 4]triazin-4-yl]am ino}-3-(2-[2-(2-methoxy phenyl) py rim idin-4-yl]methoxy} phenyl) propanoic acid (example 13) with e.g. 0.7 nM BIM_Ki in an cell free MCL-1 Bim affinity assay.

  化合物I的化学式（变量在权利要求中定义）或其药学上可接受的盐或溶剂，作为MCL-1酶抑制剂，用于治疗结肠癌、乳腺癌、小细胞肺癌、非小细胞肺癌、膀胱癌、卵巢癌、前列腺癌、慢性淋巴细胞白血病、淋巴瘤、骨髓瘤、急性髓系白血病或胰腺癌。本说明书披露了示例化合物的合成以及生物测定（例如第55至114页；段落[00216]至[00304]；示例1至33；表A和2）。例如，一种示例化合物是(2R)-2-[(5Ra)-5-3-氯-2-甲基-4-[2-(4-甲基哌嗪-1-基)乙氧基]苯基}-6-(4-氟苯基)吡咯[2，1-f][1,2,4]三嗪-4-基]氨基}-3-(2-[2-(2-甲氧基苯基)嘧啶-4-基]甲氧基}苯基)丙酸（示例13），在无细胞MCL-1 Bim亲和力测定中，其BIM_Ki为0.7 nM。
• Method and product for skin lightening
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20030044362A1

  公开（公告）日：2003-03-06

  A method and cosmetic product for lightening skin is provided, the method including wiping the skin with a cosmetic towelette. Impregnated on the towelette is an alpha-hydroxy carboxylic acid or salt thereof and a sunscreen agent.

  提供一种用于美白皮肤的方法和化妆品产品，该方法包括用化妆湿巾擦拭皮肤。湿巾上浸渍有α-羟基羧酸或其盐以及防晒剂。
• [EN] COMPOSITIONS AND METHODS FOR PARASITE CONTROL<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE LUTTE CONTRE LES PARASITES
  申请人：PHILIP MORRIS PRODUCTS SA

  公开号：WO2021260029A1

  公开（公告）日：2021-12-30

  The present invention relates in its broadest aspect to a compound of Formula I as provided herein, formulations comprising such a compound and corresponding uses thereof for the reduction of infestation with ectoparasites, in particular ectoparasites of the insect class, including fleas and mosquitoes and/or ectoparasites of the arachnid class, including ticks and mites, etc. Also provided herein are methods for preparing the formulations of the invention and methods for controlling ectoparasites using the compounds and/or formulations provided herein.

  本发明最广泛地涉及一种公式I的化合物，以及包含该化合物的制剂及其相应用途，用于减少外寄生虫的感染，特别是昆虫类的外寄生虫，包括跳蚤和蚊子，以及蜘蛛类的外寄生虫，包括蜱和螨等。本文还提供了制备本发明制剂的方法以及使用本文所提供的化合物和/或制剂控制外寄生虫的方法。
• Thickener system for cosmetic compositions
  申请人：Unilever Home & Personal Care USA, Division of Conopco Inc.

  公开号：US20030118620A1

  公开（公告）日：2003-06-26

  A cosmetic composition is provided which includes a polysaccharide and a taurate copolymer in a low pH system. The combination of polysaccharide and copolymer provides for an adequate viscosity while imparting improved skinfeel to the system.

  提供了一种化妆品组合物，其中包括多糖和牛磺酸共聚物在低pH系统中。多糖和共聚物的组合提供了足够的粘度，同时赋予系统改善的肌肤感受。