methyl 6-formyl-4,7-dihydroxy-9-oxo-5H-phenazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl 6-formyl-4,7-dihydroxy-9-oxo-5H-phenazine-1-carboxylate
• 化学式: C₁₅H₁₀N₂O₆
• 分子量: 314.25
• InChiKey: IIWPVOMPFBBVBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  洛蒙真菌素 、 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester 、 methyl 6-formyl-4,7-dihydroxy-9-oxo-5H-phenazine-1-carboxylate 生成 N-[2-(Ethylmethylamino)ethyl]-6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxamide
  参考文献：
  名称：

  Antimicrobial and antitumor phenazine carboxaldehydes and derivatives

  摘要：

  来源于6-甲酰基-4,7,9-三羟基-1-苯并咔啉羧酸甲酯和6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺表现出抗微生物和抗肿瘤活性。一株纯化的Streptomyces galanosa NRRL 15738菌株能够从含有可吸收的碳和氮源的发酵液中产生可分离的6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯。

  公开号：

  US04657909A1

文献信息

• Purified culture of streptomyces galanosa
  申请人：Warner-Lambert Company

  公开号：US04738929A1

  公开（公告）日：1988-04-19

  Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate anti-microbial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

  6-甲酰基-4,7,9-三羟基-1-苯并咔啉羧酸甲酯和6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯所衍生的酸、酯、亚胺酸、亚胺酯和亚胺酰胺表现出抗微生物和抗肿瘤活性。一种纯化的链霉菌菌株Streptomyces galanosa，编号NRRL 15738，能够从含有可同化的碳和氮源的发酵液中产生可分离的6-甲酰基-4,7,9-三羟基-8-甲基-1-苯并咔啉羧酸甲酯。
• EP2576778B1
  申请人：——

  公开号：EP2576778B1

  公开（公告）日：2017-08-09
• TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS
  申请人：Hagiwara Masatoshi

  公开号：US20130137099A1

  公开（公告）日：2013-05-30

  An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a mammalian multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a mammalian multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a mammalian multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a mammalian multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing.
• US9273364B2
  申请人：——

  公开号：US9273364B2

  公开（公告）日：2016-03-01