3,17-Dioxo-4-methyl-androsten-(4)

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,17-Dioxo-4-methyl-androsten-(4)
• 英文别名: 4,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
• 化学式: C₂₀H₂₈O₂
• 分子量: 300.441
• InChiKey: ISMVMNHPEDSOTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Use of Aromatase Inhibitors for Treatment of Ectopic Pregnancy
  申请人：Mitwally F. M. Mohamed

  公开号：US20080025991A1

  公开（公告）日：2008-01-31

  Following a diagnosis of ectopic pregnancy, at least one aromatase inhibitor, is administered to a patient, either alone or in combination with other aromatase inhibitors or therapeutic agents or as an adjuvant to conservative surgical treatment, such as laparoscopy, to prevent the establishment and/or continuation of the ectopic pregnancy. In certain preferred embodiments, the aromatase inhibitor is administered in conjunction with methotrexate.
• Use of Aromatase Inhibitors for Endometrial Thinning in Preparation for Surgical Procedures on the Endometrial Cavity and Uterus
  申请人：Mitwally F.M. Mohamed

  公开号：US20080045484A1

  公开（公告）日：2008-02-21

  Aromatase inhibitors are administered to a female patient prior to endometrial ablation or resection procedures in order to thin the endometrium to a thickness of less than 6 mm, and preferably less than 4 mm, so as to enhance the treatment outcome. Of course, administration of aromatase inhibitors would be useful for other surgical procedures on the endometrial cavity and the uterus. Commercially available aromatase inhibitors, including, the nonsteroidal preparations, anastrozole and letrozole, and a steroidal agent, exemestane, are well-tolerated, and have been shown to decrease serum estrogen levels. The aromatase inhibitor can be used alone, or in combination with other aromatase inhibitors or pharmaceutical agents, such as hormones.
• Aromatase Inhibitors for Emergency Contraception
  申请人：Casper Robert F.

  公开号：US20100105640A1

  公开（公告）日：2010-04-29

  There is disclosed an emergency contraceptive preparation which comprises at least one aromatase inhibitor wherein the preparation comprises at least one dose for administration on one or more days to a female patient following an unprotected sexual encounter until the establishment or continuation of pregnancy of the patient is prevented. Also disclosed is a method of emergency contraception.
• US7846957B2
  申请人：——

  公开号：US7846957B2

  公开（公告）日：2010-12-07
• US7820706B2
  申请人：——

  公开号：US7820706B2

  公开（公告）日：2010-10-26