1,18-Diamino-5,9,14-triazaoctadecane | 129225-32-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,18-Diamino-5,9,14-triazaoctadecane
• 英文别名: N'-[4-[3-(4-aminobutylamino)propylamino]butyl]butane-1,4-diamine
• CAS: 129225-32-7
• 化学式: C₁₅H₃₇N₅
• 分子量: 287.49
• InChiKey: ITSJFETYKWFREV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.1
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Lfa-1 inhibitors and use thereof
  申请人：Soda Kuniyasu

  公开号：US20060281820A1

  公开（公告）日：2006-12-14

  The present invention provides an LFA-1 inhibitor comprising at least one member selected from the group consisting of polyamines represented by general formula (1) and pharmaceutical acceptable salts thereof: NH 2 —(CH 2 )m1-(NH)p1-(CH 2 )m2-(NH)p2-(CH 2 )m3-(NH)p3-(CH 2 )m4-(NH)p4-(CH 2 )m5-NH 2 (1), wherein at least two of m1 to m5 exceed 0, each of m1 to m5 is independently an integer of 0 to 7, the sum of m1+m2+m3+m4+m5 is 2 or more but less than 18, at least one of p1, p2, p3 and p4 is 1, and each of others independently represents 0 or 1. The present invention also provides a pharmaceutical composition containing the LFA-1 inhibitor and a method for the inhibition or the treatment of diseases.
• LFA-1 Inhibitors and Use Thereof
  申请人：Soda Kuniyasu

  公开号：US20100004342A1

  公开（公告）日：2010-01-07

  The present invention provides an LFA-1 inhibitor comprising at least one member selected from the group consisting of polyamines represented by general formula (I) and pharmaceutical acceptable salts thereof: NH 2 —(CH 2 )m1-(NH)p1-(CH 2 )m2-(NH)p2-(CH 2 )m3-(NH)p3-(CH 2 )m4-(NH)p4-(Cl 2 )m5-NH 2 (1), wherein at least two of m1 to m5 exceed 0, each of m1 to m5 is independently an integer of 0 to 7, the sum of m1+m2+m3+m4+m5 is 2 or more but less than 18, at least one of p1, p2, p3 and p4 is 1, and each of others independently represents 0 or 1. The present invention also provides a pharmaceutical composition containing the LFA-1 inhibitor and a method for the inhibition or the treatment of diseases.
• [EN] FOOD COMPOSITION, FEED COMPOSITION COMPRISING THE FOOD COMPOSITION, AND METHOD FOR FEEDING ANIMAL BY USING THE FEED COMPOSITION<br/>[FR] COMPOSITION ALIMENTAIRE, COMPOSITION D'ALIMENTS COMPRENANT LA COMPOSITION ALIMENTAIRE, ET PROCÉDÉ POUR ALIMENTER DES ANIMAUX À L'AIDE DE LA COMPOSITION D'ALIMENTS
  申请人：UNIV JICHI MEDICAL

  公开号：WO2009093454A1

  公开（公告）日：2009-07-30

  　【課題】　食品組成物、動物の寿命を延長するための飼料組成物及び該飼料組成物を用いる動物の飼育方法を提供する。　　【解決手段】　下記式(1)のポリアミン、及びその医薬として許容し得る塩からなる群から選ばれる少なくとも１の化合物を含む、食品組成物、又は動物の寿命を延長するための飼料組成物：　NH2-(CH2)m1-(NH)p1-(CH2)m2-(NH)p2-(CH2)m3-(NH)p3-(CH2)m4-(NH)p4-(CH2)m5-NH2   …(1)