3,4-Dihydroxyphenyl-(2-piperidyl)carbinol | 32459-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,4-Dihydroxyphenyl-(2-piperidyl)carbinol
• 英文别名: (3,4-dihydroxyphenyl)(piperid-2-yl)methanol；rimiterol；4-(hydroxy-piperidin-2-yl-methyl)-benzene-1,2-diol；4-(hydroxy-2-piperidinylmethyl)-1,2-benzenediol；(3,4-dihydroxy-phenyl)-piperidin-2-yl methanol；4-[Hydroxy(piperidin-2-yl)methyl]benzene-1,2-diol
• CAS: 32459-43-1
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: IYMMESGOJVNCKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] BETA-HYDROXY HETEROCYCLIC AMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA<br/>[FR] AMINES HÉTÉROCYCLIQUES BÊTA-HYDROXY ET LEUR UTILISATION DANS LE TRAITEMENT DE L'HYPERGLYCÉMIE
  申请人：ATROGI AB

  公开号：WO2019053425A1

  公开（公告）日：2019-03-21

  There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, ring A, m and n have meanings as provided in the description.

  在此提供了一个式子(I)的化合物或其药用可接受的盐，其中X、R1、环A、m和n的含义如描述中所提供。
• Bronchodilating compositions and methods
  申请人：Dey L.P.

  公开号：US20020151597A1

  公开（公告）日：2002-10-17

  Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a derivative thereof. Methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders using the compositions provided herein are also provided.

  提供支气管扩张剂组合物和方法。这些组合物旨在作为雾化气溶胶进行管理。在某些实施例中，这些组合物含有福莫特罗或其衍生物。还提供使用此处提供的组合物治疗、预防或改善支气管收缩性疾病的一个或多个症状的方法。
• Use of Beta-Aminoalcohols for the Treatment of Inflammatory Disorders and Pain
  申请人：Baxter Andrew Douglas

  公开号：US20100016357A1

  公开（公告）日：2010-01-21

  Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein at least one of R1, R2 or R3 is not H and each is independently H, alkyl, CF 3 , CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, SOMe, SO 2 NH 2 , Salkyl, or CH 2 S0 2 alkyl; and R 4 is H or alkyl; or a salt thereof.

  可以用于治疗或预防与T细胞增殖有关或由促炎细胞因子介导的疾病的化合物的公式（I）：其中R1，R2或R3中至少一个不是H，且每个独立地是H，烷基，CF3，CONH2，CN，卤素，NH2，NO2，NHCHO，NHCONH2，NHSO2烷基，SOMe，SO2NH2，S烷基或CH2S02烷基; 而R4为H或烷基; 或其盐。
• Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
  申请人：Pipkin D. James

  公开号：US20070020299A1

  公开（公告）日：2007-01-25

  An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

  提供一种含有SAE-CD和类固醇的可吸入制剂。该制剂适用于通过任何已知的雾化器对受试者进行雾化给药。该制剂可以包含在套装中。该制剂以水溶液形式给药，但可以作为干粉、即用溶液或浓缩组合物储存。该制剂用于改进的雾化系统，通过吸入给予类固醇。制剂中的SAE-CD显著增强了布地奈德的化学稳定性。提供了一种通过吸入给药该制剂的方法。该制剂也可以通过常规的鼻腔给药器给药。
• Inhalant Formulation Containing Sulfoalkyl Ether Cyclodextrin and Corticosteroid
  申请人：PIPKIN D. JAMES

  公开号：US20070202054A1

  公开（公告）日：2007-08-30

  An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

  提供了一种含有SAE-CD和类固醇的可吸入制剂。该制剂适用于通过任何已知的雾化器对受试者进行雾化给药。该制剂可以包含在套件中。该制剂以水溶液形式给予，但可以存储为干粉、即用溶液或浓缩组成。该制剂用于改进的雾化系统中，通过吸入给药类固醇。制剂中的SAE-CD显著增强了布地奈德的化学稳定性。提供了一种通过吸入给药该制剂的方法。该制剂也可以通过传统的鼻腔给药装置进行给药。