N-(p-hydroxyphenethyl)pentacosanamide | 812665-26-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-(p-hydroxyphenethyl)pentacosanamide
• 英文别名: N-[2-(4-hydroxyphenyl)ethyl]pentacosanamide
• CAS: 812665-26-2
• 化学式: C₃₃H₅₉NO₂
• 分子量: 501.837
• InChiKey: JLWKDQDMKPFKLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  648.5±38.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  13.3
• 重原子数：
  36
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-(p-hydroxyphenethyl)pentacosanamide 在 盐酸 作用下， 以 水 为溶剂， 反应 16.0h， 以3 mg的产率得到二十五烷酸甲酯
  参考文献：
  名称：

  New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)

  摘要：

  Fractionation of a MeOH/CH2Cl2 (1/1) extract of the aerial parts of Senecio erechtitoides led to the isolation of six compounds including the hitherto unknown N-phenethylamide derivative named N-(p-hydroxyphenethyl)pentacosanamide (1), and a kauranoid derivative named derivative named ent-7-oxo-16 alpha,17-dihydroxykauran-19-oic acid (2), as well as four known compounds, ent-Kaur-16-en-19-oic acid (3), ent-7 beta-hydroxykaur-16-en-19-oic acid (4), ent-7-oxokaur-16-en-19-oic acid (5), steppogenin 4'-O-beta-D-glucoside (6). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, chemical reactions, and comparison with previously known analogs. All isolates were evaluated for their antimicrobial activity and only diterpenoids were found to possess a potent inhibitor effect against the range of microorganism. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2010.07.007

文献信息

• New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)
  作者：Jean C. Ndom、Joseph T. Mbafor、Luc M. Meva’a、Zanestsie Kakam、Arwa S. Phanuel、Etienne Ndongo、Laurence M. Harwood、Theophile N. Mpondo

  DOI：10.1016/j.phytol.2010.07.007

  日期：2010.12

  Fractionation of a MeOH/CH2Cl2 (1/1) extract of the aerial parts of Senecio erechtitoides led to the isolation of six compounds including the hitherto unknown N-phenethylamide derivative named N-(p-hydroxyphenethyl)pentacosanamide (1), and a kauranoid derivative named derivative named ent-7-oxo-16 alpha,17-dihydroxykauran-19-oic acid (2), as well as four known compounds, ent-Kaur-16-en-19-oic acid (3), ent-7 beta-hydroxykaur-16-en-19-oic acid (4), ent-7-oxokaur-16-en-19-oic acid (5), steppogenin 4'-O-beta-D-glucoside (6). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, chemical reactions, and comparison with previously known analogs. All isolates were evaluated for their antimicrobial activity and only diterpenoids were found to possess a potent inhibitor effect against the range of microorganism. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.