2-Oxo-3-phenylpiperidine-3-carbonyl chloride | 1027420-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Oxo-3-phenylpiperidine-3-carbonyl chloride
• CAS: 1027420-92-3
• 化学式: C₁₂H₁₂ClNO₂
• 分子量: 237.686
• InChiKey: HSYNASRLAIYTJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Oxo-3-phenylpiperidine-3-carbonyl chloride 、 (S)-(+)-3-喹宁醇 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 [(3S)-1-azabicyclo[2.2.2]octan-3-yl] 2-oxo-3-phenylpiperidine-3-carboxylate
  参考文献：
  名称：

  New pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity

  摘要：

  A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M(1) and M(3) receptor subtypes and an interesting activity profile in vivo. A potential use as selective bronchospasmolytic agents has been suggested for selected compounds.

  DOI：

  10.1016/0223-5234(94)90068-x
• 作为产物：
  描述：

  2-氧代-3-苯基哌啶-3-羧酸乙酯 在 氢氧化钾 、 氯化亚砜 作用下， 以 乙醇 、 苯 为溶剂， 反应 51.0h， 生成 2-Oxo-3-phenylpiperidine-3-carbonyl chloride
  参考文献：
  名称：

  New pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity

  摘要：

  A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M(1) and M(3) receptor subtypes and an interesting activity profile in vivo. A potential use as selective bronchospasmolytic agents has been suggested for selected compounds.

  DOI：

  10.1016/0223-5234(94)90068-x

文献信息

• New pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity
  作者：E Cereda、A Ezhaya、E Bellora、GB Schiavi、A Sagrada、HN Doods、A Donetti

  DOI：10.1016/0223-5234(94)90068-x

  日期：1994.1

  A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M(1) and M(3) receptor subtypes and an interesting activity profile in vivo. A potential use as selective bronchospasmolytic agents has been suggested for selected compounds.