6,9-Difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6,9-Difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate
• 英文别名: [2-(6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] 2,2-dimethylpropanoate
• 化学式: C₂₇H₃₆F₂O₆
• 分子量: 494.6
• InChiKey: JWRMHDSINXPDHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Liquid Compositions Capable of Foaming and Including Active Agents, and Methods for Making or Developing Same
  申请人：Seigfried Bernd G.

  公开号：US20110059117A1

  公开（公告）日：2011-03-10

  A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.
• METHOD FOR DEVELOPING A LIQUID COMPOSITION TO BE APPLIED TO THE SKIN AS A FOAM AND A COMPOSITION THAT CAN BE APPLIED TOPICALLY
  申请人：Seigfried Bernd G.

  公开号：US20110269704A1

  公开（公告）日：2011-11-03

  A liquid pharmaceutical composition to be applied to the skin as a foam and that has at least one solvent, at least one active pharmaceutical ingredient, and at least one foaming agent. The foam volume and the foam stability are determined according to a standardized SITA measuring method. The foaming agent, the solvent, and the active pharmaceutical ingredient are varied in regard to the chemical type and/or concentration thereof until the foam thus produced by the SITA measuring method has a foam volume of at least 400 ml and such foam stability that after a dwell time of up to ten minutes the foam still has at least 50% of the foam volume that originally existed immediately after the foam was produced.
• LIQUID COMPOSITIONS CAPABLE OF FOAMING AND INCLUDING ACTIVE AGENTS, AND METHODS FOR MAKING OR DEVELOPING SAME
  申请人：MIKA Pharma GmbH

  公开号：US20180104185A1

  公开（公告）日：2018-04-19

  A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.
• US4455146A
  申请人：——

  公开号：US4455146A

  公开（公告）日：1984-06-19
• US9005626B2
  申请人：——

  公开号：US9005626B2

  公开（公告）日：2015-04-14