5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,5,16beta-trihydroxy-, 16-acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,5,16beta-trihydroxy-, 16-acetate
• 英文别名: [14,16-dihydroxy-7,11-dimethyl-6-(6-oxopyran-3-yl)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-5-yl] acetate
• 化学式: C₂₆H₃₄O₇
• 分子量: 458.5
• InChiKey: KBKUJJFDSHBPPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PALIURUS RAMOSISSIMUS (LOUR.) POIR EXTRACT AND PREPARATION METHOD AND USES THEREOF
  申请人：Sichuan Academy of Chinese Medicine Sciences

  公开号：EP3064212A1

  公开（公告）日：2016-09-07

  New uses of Paliurus ramosissimus (Lour.) Poir and the Paliurus ramosissimus (Lour.) Poir extract, comprise uses in preparing medicines having anti-fibrosis effects, antifungal activity, antitumor activity, dual immunomodulatory activity and for treating inflammations or (and) ulcers of the oral cavity and digestive tract.

  巴戟天和巴戟天提取物的新用途包括用于制备具有抗纤维化作用、抗真菌活性、抗肿瘤活性、双重免疫调节活性以及治疗口腔和消化道炎症或（和）溃疡的药物。
• APPLICATION OF LARGE-DOSE GLYCERINUM IN FREEZE-THAWING TOLERABLE LIPID EMULSION
  申请人：Shenyang Pharmaceutical University

  公开号：EP3156045A1

  公开（公告）日：2017-04-19

  The invention relates to fat emulsions, particularly to a use of high-concentrationglycerol in freeze-thaw resistant emulsions and a free-thaw resistant emulsion thereof. The said high-concentrationglycerol is the glycerol that is greater than or equal to 3 w/v % in the emulsion composition. The maximum percentage of the glycerol in the emulsion is 50 w/v %. When the percentage of the oil in the emulsion is 2%-30 w/v %, the glycerol is more than or equal to 1/3 of the oil in the emulsion. The invention comprises adrug-contained emulsion through including drugs. Compared with prior arts, the invention provides a freeze-thaw resistant emulsion which tolerates the low-temperature freeze-thaw experiments, avoiding the pharmaceutical stability issues due to the temperature changes during the emulsion transport, storage and utilization, ensuring medicine quality, meanwhile it drastically reduces the requirements of the transport and storage conditions as well as the medicine costs.

  本发明涉及脂肪乳剂，特别是在抗冻融乳剂中使用高浓度甘油及其抗自由解冻乳剂。所述高浓度甘油是指在乳液组合物中大于或等于 3 w/v % 的甘油。甘油在乳液中的最大百分比为 50 w/v%。当乳剂中油的百分比为 2%-30 w/v % 时，甘油大于或等于乳剂中油的 1/3。本发明包括通过包含药物的含药乳剂。与现有技术相比，本发明提供了一种耐冻融乳剂，可耐受低温冻融实验，避免了乳剂在运输、储存和使用过程中因温度变化而产生的药物稳定性问题，保证了药品质量，同时大大降低了对运输、储存条件的要求，降低了药品成本。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Pulmonary hypertension preventative or therapeutic agent containing component exhibiting selenoprotein P activity-inhibiting effect
  申请人：TOHOKU UNIVERSITY

  公开号：US10624883B2

  公开（公告）日：2020-04-21

  A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing an ingredient having a selenoprotein P activity-inhibiting action.

  本发明要解决的一个问题是提供一种新型的肺动脉高压预防或治疗剂，其活性成分含有一种迄今为止尚未发现对肺动脉高压有治疗作用的化合物。 本发明提供了一种肺动脉高压的预防或治疗剂，其中含有一种具有硒蛋白 P 活性抑制作用的成分。
• Paliurus ramosissimus (Lour.) Poir. extract and preparation methods and uses thereof
  申请人：Sichuan Academy of Chinese Medicine Sciences

  公开号：US10987395B2

  公开（公告）日：2021-04-27

  The invention belongs to the field of medicine, involving new uses of Paliurus ramosissimus (Lour.) Poir. and its extract, in particular the use of Paliurus ramosissimus (Lour.) Poir. and its extract in preparation of drugs with anti-fibrotic, anti-fungal, and anti-tumor activities, for the treatment of oral and digestive tract inflammation or (and) ulcer-related diseases, or with bi-directional immunomodulatory effects.

  本发明属于医药领域，涉及巴戟天（Paliurus ramosissimus (Lour.) Poir.）及其提取物的新用途，特别是将巴戟天（Paliurus ramosissimus (Lour.) Poir.）及其提取物用于制备具有抗纤维化、抗真菌和抗肿瘤活性的药物，用于治疗口腔和消化道炎症或（和）溃疡相关疾病，或具有双向免疫调节作用。