C17-Sphinganine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: C17-Sphinganine
• 英文别名: 2-aminoheptadecane-1,3-diol
• 化学式: C₁₇H₃₇NO₂
• 分子量: 287.5
• InChiKey: KFQUQCFJDMSIJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Compositions and methods for treating hyperproliferative disorders
  申请人：TEXAS TECH UNIVERSITY

  公开号：EP2669267A1

  公开（公告）日：2013-12-04

  A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.; A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred hyperproliferative disorder is brain cancers.

  一种治疗需要这种治疗的受试者的过度增殖性疾病的方法，包括向所述受试者联合施用治疗有效量的以下物质：(a) 神经酰胺增加型维甲酸，如芬瑞替尼或其药学上可接受的盐；(b) 至少一种（在某些实施方案中至少两种）选自以下组别的化合物：(i) 非 18 碳链长度的 L-苏-鞘氨醇或其药学上可接受的盐；(ii) 葡萄糖甘油酰胺或葡萄糖（二氢）神经酰胺合成抑制剂；(iii) 鞘磷脂或二氢鞘磷脂合成酶抑制剂。优选的 L-硫代鞘磷脂的碳链长度为 17 碳、19 碳和 20 碳。一种优选的葡糖基甘油酰胺或葡糖基（二氢）神经酰胺合成抑制剂是 D-苏-1-苯基-2-棕榈酰氨基-3-吗啉基-1-丙醇；一种优选的鞘磷脂或二氢鞘磷脂合成抑制剂是 D-苏-1-苯基-2-棕榈酰氨基-3-吗啉基-1-丙醇。一种优选的过度增殖性疾病是脑癌。
• Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
  申请人：Cullis R. Pieter

  公开号：US20060008909A1

  公开（公告）日：2006-01-12

  The present invention includes novel liposomes comprising dihydrosphingomyelin. The invention also includes compositions comprising these liposomes and a therapeutic agent, in addition to methods and kits for delivering a therapeutic agent or treating a disease, e.g., a cancer, using these compositions.

  本发明包括包含二氢鞘氨醇的新型脂质体。本发明还包括包含这些脂质体和治疗剂的组合物，以及使用这些组合物递送治疗剂或治疗疾病（如癌症）的方法和试剂盒。
• LIPOSOMAL FORMULATIONS COMPRISING DIHYDROSPHINGOMYELIN AND METHODS OF USE THEREOF
  申请人：Inex Pharmaceuticals Corporation

  公开号：EP1750673A2

  公开（公告）日：2007-02-14
• COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS
  申请人：TEXAS TECH UNIVERSITY

  公开号：EP2501672A2

  公开（公告）日：2012-09-26
• METHODS AND ASSAYS FOR USE IN DIAGNOSIS OF LAMINITIS
  申请人：Pepsis Limited

  公开号：EP3773919A1

  公开（公告）日：2021-02-17