Methanaminium, N,N,N-trimethyl-1-[(2-methyl-1-oxo-2-propenyl)oxy]- | 44986-60-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methanaminium, N,N,N-trimethyl-1-[(2-methyl-1-oxo-2-propenyl)oxy]-
• 英文别名: trimethyl(2-methylprop-2-enoyloxymethyl)azanium
• CAS: 44986-60-9
• 化学式: C8H16NO2+
• 分子量: 158.22
• InChiKey: FFFSEOGYLUUFMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Coating composition including a salt having a silsesquioxane anion
  申请人：LG CHEM, LTD.

  公开号：US10767056B2

  公开（公告）日：2020-09-08

  A coating composition having excellent anti-static properties and suitable for use as anti-static hard coating films. The coating composition comprises a radical polymerizable binder and a salt based on an anion including a cage-shaped frame. The anti-static hard coating film formed using the coating composition has excellent anti-static properties, abrasion resistance and moist heat resistance. Such film may be used for an optical laminate a display device, and the like.

  一种涂层组合物具有优异的抗静电性能，适合用作抗静电硬涂层薄膜。该涂料组合物由可自由基聚合的粘合剂和基于阴离子的盐组成，阴离子包括笼形框架。使用该涂层组合物形成的抗静电硬质涂膜具有优异的抗静电性能、耐磨性和耐湿热性。这种薄膜可用于光学层压板、显示设备等。
• Coating composition
  申请人：LG CHEM, LTD.

  公开号：US11390717B2

  公开（公告）日：2022-07-19

  The coating composition of the present application has excellent antistatic properties and thus can be used as an antistatic hard coating film. The coating composition of the present application may comprise a salt based on a polyoxometalate anion and a radically polymerizable cation, and a radically polymerizable binder to form an antistatic hard coating film having excellent antistatic property, abrasion resistance and moist-heat resistance. Such a film can be used for an optical laminate and a display device, and the like.

  本申请的涂层组合物具有优异的抗静电性能，因此可用作抗静电硬质涂膜。本申请的涂层组合物可包含一种基于聚氧化金属阴离子和可辐射聚合阳离子的盐，以及一种可辐射聚合的粘合剂，以形成具有优异抗静电性能、耐磨性和耐湿热性的抗静电硬质涂膜。这种薄膜可用于光学层压板和显示设备等。
• Composition for pulsatile delivery of diltiazem and process of manufacture
  申请人：——

  公开号：US20030003149A1

  公开（公告）日：2003-01-02

  A once-a-day controlled release drug delivery system of diltiazem hydrochloride is provided, which is bioequivalent in plasma profile of Cardizem CD. The fast, medium, and slow release fractions are prepared using various compositions and weight gains. The individual fill weights are computed and then are filled into the same capsule using specialized encapsulation equipment using a triple-filling process. A preferred membrane dispersion that is used for preparing the fast release fraction contains 0.2% of sodium lauryl sulfate along with 20% of water soluble plasticizer (triethyl citrate), and 2% silicone dioxide, based on quaternary polymethacrylate on the weight basis. This combination provides an initial pulsatile burst after a lag time of 2 hours, leading to in-vivo bioequivalence. The preferred membrane dispersion that is used for preparing the medium release and the slow release fractions contain 16% of water soluble plasticizer along with 5% silicone dioxide, based on quaternary polymethacrylate. This combination provides an optimal glass transition temperature that allows for the preparation of exceptionally increased weight gains. Additionally, it provides targeted input of drug release for achieving bioequivalence. Regardless of significant in-vitro inequivalence to the release rate profile of the innovator product, the in vivo-equivalence data comply with required regulatory guidelines.

  本研究提供了一种盐酸地尔硫卓的一日一次控释给药系统，其血浆特征与 Cardizem CD 具有生物等效性。使用不同的成分和重量增量制备了快释、中释和缓释馏分。计算出各个填充重量后，使用专门的封装设备，采用三重填充工艺将其填充到同一个胶囊中。用于制备快速释放部分的优选膜分散体含有 0.2% 的十二烷基硫酸钠和 20% 的水溶性增塑剂（柠檬酸三乙酯），以及 2% 的二氧化硅（以季铵聚甲基丙烯酸酯的重量为基础）。这种组合可在滞后 2 小时后提供初始脉冲爆发，从而实现体内生物等效性。用于制备中释和缓释馏分的优选膜分散体含有 16% 的水溶性增塑剂和 5% 的二氧化硅（以季铵型聚甲基丙烯酸酯为基础）。这种组合提供了最佳的玻璃化转变温度，使制备的增重效果特别好。此外，它还能有针对性地释放药物，实现生物等效性。尽管体外试验与创新产品的释放率曲线存在明显的不等效性，但体内等效性数据符合规定的监管准则。
• ORAL DOSAGE FORM, COMPRISING AT LEAST ONE BIOLOGICALLY ACTIVE AGENT, FORMULATION AUXILIARY SUBSTANCES AND MAGNETIZABLE PARTICLES
  申请人：Evonik Röhm GmbH

  公开号：EP2473095B1

  公开（公告）日：2014-11-12
• COATING COMPOSITION
  申请人：LG Chem, Ltd.

  公开号：EP3536752B1

  公开（公告）日：2021-12-29