2,2,3,3,4,4,4-heptafluoro-N-(2-hydroxyethyl)butanamide | 377-66-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2,2,3,3,4,4,4-heptafluoro-N-(2-hydroxyethyl)butanamide
• 英文别名: heptafluoro-butyric acid-(2-hydroxy-ethylamide)；Heptafluor-buttersaeure-(2-hydroxy-aethylamid)
• CAS: 377-66-2
• 化学式: C₆H₆F₇NO₂
• 分子量: 257.108
• InChiKey: KPTAUHCSUNOZRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,2,3,3,4,4,4-heptafluoro-N-(2-hydroxyethyl)butanamide 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以90 %的产率得到2-((2,2,3,3,4,4,4-heptafluorobutyl)amino)ethan-1-ol
  参考文献：
  名称：

  FLUORINATED ZWITTERIONIC POLYMERS AND METHODS OF USE

  摘要：

  Fluorinated monomer compositions having the formula: A-L-Z (1), wherein A is a polymerizable group (e.g., a vinyl group); L is a bond or linking portion; Z is a zwitterionic moiety or a zwitterionic precursor moiety containing a protecting group capable of deprotection to form a charged group; wherein at least one hydrogen atom in A, L, and/or Z in Formula (1) is substituted by a fluorinated hydrocarbon group, wherein the fluorinated hydrocarbon group contains 1-12 carbon atoms and precisely or at least one, two, three, four, five, or six fluorine atoms. Also described herein are fluorinated zwitterionic polymers derived from such monomers. Also described herein are mixed-charge zwitterionic polymers. Other aspects include methods for producing the monomers and polymers, bulk material (e.g., hydrogel or copolymer hybrid) compositions of any of the zwitterionic polymers described herein, fouling-resistant and/or fouling releasing surfaces and objects, and nanoparticles containing the polymer or bulk material.

  公开号：

  WO2023249926A2
• 作为产物：
  描述：

  七氟丁酸甲酯 、 C.I.酸性橙108 以 乙醚 为溶剂， 反应 3.0h， 以70%的产率得到2,2,3,3,4,4,4-heptafluoro-N-(2-hydroxyethyl)butanamide
  参考文献：
  名称：

  Synthesis of polyfluoroalkylated 1,4-diazinols and 1,4-oxazinols using polyfluoro-2,3-epoxyalkanes32 + 13

  摘要：

  It has been found that the reactions of polyfluoro-2,3-epoxyalkanes with ethylenediamine and 2-aminoethanol yield 2,3-di(polyfluoroalkyl)- 1,5,6-trihydro-1,4-diazin-2-ols and 2,3-di(polyfluoroalkyl)-5,6-dihydro-1,4-oxazin-2-ols, respectively. In the case of unsymmetrical oxiranes mixtures of regioisomeric heterocyclic compounds have been obtained. These reactions were found to give some by products-N,N'-bis(polyfluoroacyl) ethylenediamines and N-polyfluoroacyl-2-aminoethanols. (C) 1998 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00102-4

文献信息

• Photocatalytic amidation and esterification with perfluoroalkyl iodide
  作者：Yelan Xiao、Yuen-Kiu Chun、Shun-Cheung Cheng、Chi-On Ng、Man-Kit Tse、Ngai-Yu Lei、Ruoyang Liu、Chi-Chiu Ko

  DOI：10.1039/d0cy01419b

  日期：——

  The successful generation of perfluoroalkyl radicals (Rf˙) through photoredox catalysis has inspired us to investigate the preparation of various organofluorine species. In this work, visible light-induced photocatalytic reactions for the preparation of perfluoroalkyl amides and esters from the corresponding amines and alcohols using different types of triplet emitters as photocatalysts have been studied

  成功生成全氟烷基（Rf˙）通过光氧化还原催化激发了我们研究各种有机氟物质的制备。在这项工作中，已经研究了可见光诱导的光催化反应，该反应使用不同类型的三重态发光体作为光催化剂，由相应的胺和醇制备全氟烷基酰胺和酯。已经阐明了光催化剂的激发态特性和氧化还原电势的影响。在优化的反应条件下，可以使用不同类型的胺或醇和全氟烷基碘成功地进行这些反应。已经基于发射猝灭实验进行了详细的机理研究，以研究光催化循环以及不同试剂的作用。提议的机制也已通过DFT计算进行了检查。
• Saloutina; Zapevalov; Kodess, Russian Journal of Nondestructive Testing, 1997, vol. 33, # 2, p. 265 - 272
  作者：Saloutina、Zapevalov、Kodess、Saloutin

  DOI：——

  日期：——
• The Reaction of Ethyl Perfluorobutyrate with Sodium. An Improved Synthesis of Perfluoroheptan-4-one
  作者：Murray Hauptschein、Robert A. Braun

  DOI：10.1021/ja01623a077

  日期：1955.9
• Synthesis of polyfluoroalkylated 1,4-diazinols and 1,4-oxazinols using polyfluoro-2,3-epoxyalkanes32 + 13
  作者：L.V. Saloutina、A.Ya. Zapevalov、M.I. Kodess、V.I. Saloutin

  DOI：10.1016/s0022-1139(97)00102-4

  日期：1998.1

  It has been found that the reactions of polyfluoro-2,3-epoxyalkanes with ethylenediamine and 2-aminoethanol yield 2,3-di(polyfluoroalkyl)- 1,5,6-trihydro-1,4-diazin-2-ols and 2,3-di(polyfluoroalkyl)-5,6-dihydro-1,4-oxazin-2-ols, respectively. In the case of unsymmetrical oxiranes mixtures of regioisomeric heterocyclic compounds have been obtained. These reactions were found to give some by products-N,N'-bis(polyfluoroacyl) ethylenediamines and N-polyfluoroacyl-2-aminoethanols. (C) 1998 Elsevier Science S.A.
• FLUORINATED ZWITTERIONIC POLYMERS AND METHODS OF USE
  申请人：[en]CORNELL UNIVERSITY

  公开号：WO2023249926A2

  公开（公告）日：2023-12-28

  Fluorinated monomer compositions having the formula: A-L-Z (1), wherein A is a polymerizable group (e.g., a vinyl group); L is a bond or linking portion; Z is a zwitterionic moiety or a zwitterionic precursor moiety containing a protecting group capable of deprotection to form a charged group; wherein at least one hydrogen atom in A, L, and/or Z in Formula (1) is substituted by a fluorinated hydrocarbon group, wherein the fluorinated hydrocarbon group contains 1-12 carbon atoms and precisely or at least one, two, three, four, five, or six fluorine atoms. Also described herein are fluorinated zwitterionic polymers derived from such monomers. Also described herein are mixed-charge zwitterionic polymers. Other aspects include methods for producing the monomers and polymers, bulk material (e.g., hydrogel or copolymer hybrid) compositions of any of the zwitterionic polymers described herein, fouling-resistant and/or fouling releasing surfaces and objects, and nanoparticles containing the polymer or bulk material.