4-Methylcholest-7-en-3-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-Methylcholest-7-en-3-ol
• 英文别名: 4,10,13-trimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 化学式: C₂₈H₄₈O
• 分子量: 400.7
• InChiKey: LMYZQUNLYGJIHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• DRUGS, FOOD OR DRINK FOR IMPROVING PANCREATIC FUNCTIONS
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1808175A1

  公开（公告）日：2007-07-18

  Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink.

  4-甲基胆甾-7-烯-3-醇、4-甲基麦角甾-7-烯-3-醇和 4-甲基豆甾-7-烯-3-醇等化合物具有改善胰腺功能的活性，可用作改善胰腺功能的药物和食品或饮料的活性成分。
• VISCERAL FAT ACCUMULATION INHIBITOR
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1927360A1

  公开（公告）日：2008-06-04

  To reduce amounts of fat accumulated in abdominal cavity and to prevent or ameliorate visceral fat type obesity, considered to be a main factor of metabolic syndrome, the present invention provides an agent or a food or drink which contains a compound having a lophenol skeleton, or an organic solvent extract or a hot water extract of a Liliaceae plant, or a fraction thereof containing the compound is used as an active ingredient.

  为了减少腹腔积聚的脂肪量，预防或改善被认为是代谢综合征主要因素的内脏脂肪型肥胖症，本发明提供了一种药剂或一种食品或饮料，其中含有一种具有洛芬诺骨架的化合物，或一种百合科植物的有机溶剂提取物或热水提取物，或含有该化合物的馏分作为活性成分使用。
• AGENT FOR AMELIORATION OF INSULIN RESISTANCE
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1930341A1

  公开（公告）日：2008-06-11

  To inhibit production of adipocytokines, in particular, adipocytokines that elicit insulin resistance and to prevent onset of pathosis caused by the insulin resistance or ameliorate the pathosis, the present invention provides an agent or a food or drink which contains a compound having a lophenol skeleton, or an organic solvent extract or a hot water extract of a Liliaceae plant or, a fraction thereof containing the compound as an active ingredient.

  为了抑制脂肪细胞因子的产生，特别是抑制引起胰岛素抵抗的脂肪细胞因子的产生，并防止胰岛素抵抗引起的病症的发生或改善病症，本发明提供了一种药剂或一种食品或饮料，其中含有一种具有洛酚骨架的化合物，或一种百合科植物的有机溶剂提取物或热水提取物，或含有该化合物作为活性成分的其馏分。
• ALOE VERA EXTRACT, PROCESS FOR PRODUCTION OF ALOE VERA EXTRACT, AND AMELIORATING AGENT FOR HYPERGLYCEMIA
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1952817A1

  公开（公告）日：2008-08-06

  The present invention provides: an Aloe vera extract that can be safely ingested, can be used as a material of food for preventing lifestyle diseases, contains an extremely low level of an anthraquinone (anthraquinone-based compound), and can be added to foods; and a method of producing the Aloe vera extract. A supercritical fluid extraction method can produce an Aloe vera extract containing a mixture that consists of a cyclolanostane compound and a lophenol compound in an amount of 1.0% by mass or more and having the following properties (1) and/or (2): (1) the mass mixing ratio of the cyclolanostane compound and lophenol compound is as follows: cyclolanostane compound : lophenol compound = 6.3 : 2.7 to 5.1 : 4.9; and/or (2) the content of an anthraquinone-based compound is 0.001% by mass or less.

  本发明提供了：一种可安全摄入、可用作预防生活习惯病的食品原料、含有极低水平的蒽醌（蒽醌类化合物）、可添加到食品中的芦荟提取物；以及一种芦荟提取物的生产方法。超临界流体萃取法可以生产出一种芦荟提取物，该提取物含有一种由环羊毛甾烷化合物和洛酚化合物组成的混合物，其质量分数为 1.0% 或以上，并具有以下特性（1）和/或（2）： (1) 环羊毛甾烷化合物和洛酚化合物的质量混合比如下： 环羊毛甾化合物：氯酚化合物 = 6.3 : 2.7 至 5.1 ：4.9；和/或 (2) 蒽醌类化合物的含量为 0.001%（质量百分比）或以下。
• AGENT FOR INHIBITING VISCERAL FAT ACCUMULATION
  申请人：MORINAGA MILK INDUSTRY CO., LTD.

  公开号：EP1927360B1

  公开（公告）日：2014-01-22