Calotoxin | 20304-49-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Calotoxin
• 英文别名: 8,9,10,22-tetrahydroxy-7,18-dimethyl-19-(5-oxo-2H-furan-3-yl)-4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-14-carbaldehyde
• CAS: 20304-49-8
• 化学式: C₂₉H₄₀O₁₀
• 分子量: 548.6
• InChiKey: LYSHVSOMKBORDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  39
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  10

ADMET

毒理性

• 副作用

职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒病例。

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 非人类毒性摘录

牛吃了毒草的后果对牧场主来说仍然是个问题，尤其是在没有足够的可饮用牧草或者毒草被混入割下来的饲料中时。神经和胃肠症状包括抑郁、冷漠、虚弱、失去肌肉控制、跌倒、瞳孔扩大、呼吸麻痹、肠道停滞和发酵，偶尔还会出现腹泻。有时还会看到破伤风样发作。症状可能在摄入植物后2小时就开始，并可能持续数小时或数天。中毒的动物在死亡前可能经历一段昏迷期，也可能不会。死亡时的病变包括急性卡他性胃肠炎和肺充血，有时还会涉及肾脏。/毒草中毒/

MILKWEED POISONING IN...CATTLE REMAINS A PROBLEM TO RANCHERS, PARTICULARLY WHEN ADEQUATE QUANTITIES OF POTABLE FORAGE ARE UNAVAILABLE OR WHEN MILKWEEDS ARE INCORPORATED IN CUT FEED. ... NERVOUS & GASTROINTESTINAL SYMPTOMS INCLUDE DEPRESSION AND APATHY, WEAKNESS, LOSS OF MUSCLE CONTROL, FALLING, DILATED PUPILS, RESPIRATORY PARALYSIS, INTESTINAL STASIS AND FERMENTATION, AND OCCASIONALLY, DIARRHEA. SOMETIMES TETANIC SEIZURES ARE SEEN. ...SYMPTOMS MAY BEGIN AS EARLY AS 2 HR AFTER INGESTION OF THE PLANT & MAY CONTINUE FOR HR OR DAYS. A POISONED ANIMAL MAY OR MAY NOT EXPERIENCE A PERIOD OF COMA BEFORE DYING. LESIONS AT DEATH INCLUDE ACUTE CATARRHAL GASTROENTERITIS AND CONGESTION OF THE LUNGS & SOMETIMES OF THE KIDNEYS. /MILKWEED POISONING/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

C procera在沙漠羊中的急性毒性研究，通过口服途径给予单次或多次剂量（6.0至0.001毫升/千克）的乳液，导致死亡。动物出现神经系统症状、排尿、心动过速、呼吸困难和精神状态下降。在肝脏、肾脏、心脏、肺、大脑和肠道观察到严重的病理变化，与血清中的代谢变化相关。肝脏、心脏和肾脏中总脂质浓度增加。

Acute toxicity of C procera was studied in Desert sheep given single or multiple doses (6.0 to 0.001 ml/kg) of the latex by oral route, it caused death. The animals developed nervous signs, urination, tachycardia, dyspnea and loss of condition. Severe pathological changes were seen in the liver, kidneys, heart, lungs, brain & intestines, correlated with metabolic changes in the serum. The concn of total lipids in the liver, heart and kidneys was increased.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

C procera的急性毒性在沙漠羊中进行了研究，通过静脉途径给予单次或多次剂量（6.0至0.001毫升/千克），导致两种动物死亡。动物表现出神经症状、排尿、心动过速、呼吸困难和精神状态下降。在肝脏、肾脏、心脏、肺、大脑和肠中观察到严重的病理变化，与血清中的代谢变化有关。肝脏、心脏和肾脏中总脂质浓度增加。

Acute toxicity of C procera was studied in Desert sheep given single or multiple doses (6.0 to 0.001 ml/kg) of the latex by iv route, it caused death in both species. The animals developed nervous signs, urination, tachycardia, dyspnea and loss of condition. Severe pathological changes were seen in the liver, kidneys, heart, lungs, brain & intestines, correlated with metabolic changes in the serum. The concn of total lipids in the liver, heart and kidneys was increased.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

C procera的急性毒性在沙漠绵羊中进行了研究，通过腹腔注射单一或多剂量的乳液（6.0至0.001毫升/千克），导致死亡。动物出现神经系统症状、排尿、心动过速、呼吸困难和精神状态下降。在肝脏、肾脏、心脏、肺、大脑和肠中发现严重的病理变化，与血清中的代谢变化有关。肝脏、心脏和肾脏中总脂质浓度增加。

Acute toxicity of C procera was studied in Desert sheep given single or multiple doses (6.0 to 0.001 ml/kg) of the latex by ip route, it caused death. The animals developed nervous signs, urination, tachycardia, dyspnea and loss of condition. Severe pathological changes were seen in the liver, kidneys, heart, lungs, brain & intestines, correlated with metabolic changes in the serum. The concn of total lipids in the liver, heart and kidneys was increased.

来源:Hazardous Substances Data Bank (HSDB)